Results 31 to 40 of about 2,402,104 (309)
A Review on Notch Signaling and Colorectal Cancer
Cells, 2020 Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway.
Ashish Tyagi +2 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, 2020 Results from various studies reveal that the role of G protein‐coupled oestrogen receptor (GPER) is cancer‐context dependent, and the function of GPER in non–small‐cell lung cancer (NSCLC) is still unclear.
Yisong Shen +3 more
semanticscholar +1 more source
The Notch1 receptor is cleaved constitutively by a furin-like convertase [PDF]
Proceedings of the National Academy of Sciences, 1998 The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that proteolytic processing of p300 is an essential step in the formation of the biologically active receptor because only the cleaved fragments are present at the cell ...
Logeat, F. +6 more
openaire +3 more sources
Sequential Signaling through Notch1 and erbB Receptors Mediates Radial Glia Differentiation [PDF]
The Journal of Neuroscience, 2003 Radial glia cells both generate neurons and physically guide nascent neurons to their target destination in the cortex, and as such they are essential for CNS development. It has been proposed that in the developing cerebellum, neuronal contact induces radial glia formation, however, the mechanisms involved in this process are not well understood. Here
Brooke A, Patten +3 more
openaire +2 more sources
Cells, 2020 Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key feature of malignant gliomas is their cellular heterogeneity. In particular, the presence of an undifferentiated cell population of defined Glioblastoma Stem cells (
I. Cristofaro +9 more
semanticscholar +1 more source
Inhibition of HDAC6 Attenuates Tumor Growth of Non-Small Cell Lung Cancer
Translational Oncology, 2020 Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through deacetylation of various cytoplasmic substrates and serves as a key member of the ubiquitin proteasome system (UPS).
Brian Deskin +5 more
doaj +1 more source
CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation
Cancer Medicine, 2021 The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu +4 more
doaj +1 more source
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]
, 2010 Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Barbara M. Grüner +9 more
core +7 more sources
Scientific Reports, 2021 The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays a crucial role in angiogenesis at least in part through participating in endocytosis and, thereby, endosomal signaling of several cell surface receptors including VEGF receptor-2 ...
Shota Shimizu +3 more
doaj +1 more source