Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 [PDF]
Cancer Research, 2015 Abstract The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin ...
Mazzieri Roberta +11 more
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Scientific Reports, 2023 Notch signaling is an evolutionarily conserved mechanism required for numerous types of cell fate decisions in metazoans. It mediates short-range communication between cells with receptors and ligands, both of which are expressed on the cell surfaces. In
Wataru Masuda +11 more
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Molecular Oncology, 2021 The cellular receptor Notch1 is a central regulator of T‐cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T‐cell acute lymphoblastic leukemia (T‐ALL).
Tra Ly Nguyen +24 more
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A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
Frontiers in Pharmacology, 2023 Although breast cancer stem cells (BCSCs) are well characterized, molecularly targeting and eradicating this sub-population remains a challenge in the clinic.
Uttara Saran +6 more
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Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
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Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis [PDF]
Gut, 2016 Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design Mice were treated with the pan-Notch inhibitor dibenzazepine (DBZ) or ...
Gail B, Gifford +11 more
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Molecular Characterization of Notch1 Positive Progenitor Cells in the Developing Retina. [PDF]
PLoS ONE, 2015 The oscillatory expression of Notch signaling in neural progenitors suggests that both repressors and activators of neural fate specification are expressed in the same progenitors.
Galina Dvoriantchikova +7 more
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Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. [PDF]
, 2013 Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry.
Abdi, Khadar +9 more
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G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition [PDF]
Cell Research, 2015 In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through the endothelial-to-hematopoietic transition (EHT). Notch signaling is essential for HSPC development during embryogenesis across vertebrates.
Zhang, Panpan +9 more
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A Novel PAK1–Notch1 Axis Regulates Crypt Homeostasis in Intestinal InflammationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine kinases and contributes to cellular pathways such as nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein ...
Adrian Frick +9 more
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