Results 41 to 50 of about 83,203 (255)
In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. [PDF]
PLoS ONE, 2013 Mechanosensory hair cells (HCs) and surrounding supporting cells (SCs) in the mouse cochlea are important for hearing and are derived from the same prosensory progenitors.
Zhiyong Liu +5 more
doaj +1 more source
NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]
, 2018 Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana +14 more
core +2 more sources
Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer [PDF]
Cancer Science, 2012 Notch functions as an oncogene or tumor suppressor according to the type of malignancy, and the BRAFV600E mutation is commonly observed in thyroid cancer. However, the role of Notch and BRAFV600E in papillary thyroid cancer (PTC) is unclear. This study sought to elucidate the clinicopathological characteristics in patients with PTC regarding the ...
Hyung Seok, Park +9 more
openaire +2 more sources
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +1 more source
Cancer Cell International, 2018 Background Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies.
Yang Zheng +9 more
doaj +1 more source
Notch signaling during human T cell development [PDF]
, 2012 Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy +97 more
core +2 more sources
Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac Anomalies [PDF]
Circulation: Cardiovascular Genetics, 2015 Background— Adams–Oliver syndrome (AOS) is a rare disorder characterized by congenital limb defects and scalp cutis aplasia. In a proportion of cases, notable cardiac involvement is also apparent. Despite recent advances in the understanding of the genetic basis of AOS, for the majority of affected subjects, the underlying ...
Southgate Laura +19 more
openaire +5 more sources
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway [PDF]
The Journal of Experimental Medicine, 2008 In the damaged heart, cardiac adaptation relies primarily on cardiomyocyte hypertrophy. The recent discovery of cardiac stem cells in the postnatal heart, however, suggests that these cells could participate in the response to stress via their capacity to regenerate cardiac tissues.
Croquelois, A. +6 more
openaire +4 more sources
Cancer Biology & Medicine, 2009 OBJECTIVE Notch1 signaling has been implicated in tumorigenesis. The purpose of this study was to investigate the putative role of the Notch1 receptor in carcinogenesis and in the progression of the cervical cancer.
Li SUN, Yongmei SONG, Tong TONG
doaj +1 more source
Oncogenesis, 2021 Epidermal growth factor receptor (EGFR) remains the sole druggable molecular target other than the PD1/PD-L1 pathway with meaningful clinical benefit in squamous cell carcinoma of head and neck (SCCHN).
Yi-Ping Wang +3 more
doaj +1 more source