Results 41 to 50 of about 2,402,104 (309)

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics of Notch1 heterozygous mice in a high-cholesterol diet model

PLoS ONE, 2020
Calcific aortic valve disease (CAVD) is a deadly disease that is rising in prevalence due to population aging. While the disease is complex and poorly understood, one well-documented driver of valvulopathy is serotonin agonism.
J. Joll, Cynthia R. Clark, Christine S. Peters, M. A. Raddatz, M. Bersi, W. D. Merryman   +5 more
semanticscholar   +1 more source

TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors

Scientific Reports, 2023
Notch signaling is an evolutionarily conserved mechanism required for numerous types of cell fate decisions in metazoans. It mediates short-range communication between cells with receptors and ligands, both of which are expressed on the cell surfaces. In
Wataru Masuda, Tomoko Yamakawa, Rieko Ajima, Katsuya Miyake, Toshifumi Umemiya, Kazuhiko Azuma, Jun-ichi Tamaru, Makoto Kiso, Puspa Das, Yumiko Saga, Kenji Matsuno, Motoo Kitagawa   +11 more
doaj   +1 more source

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Notch1 and Notch2 receptors influence progressive hair graying in a dose‐dependent manner [PDF]

Developmental Dynamics, 2006
AbstractThe Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP‐Jκ, Notch1, and Notch2 conditional knockout mice.
Karine, Schouwey, Véronique, Delmas, Lionel, Larue, Ursula, Zimber-Strobl, Lothar J, Strobl, Freddy, Radtke, Friedrich, Beermann   +6 more
openaire   +2 more sources

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

Molecular Oncology, 2021
The cellular receptor Notch1 is a central regulator of T‐cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T‐cell acute lymphoblastic leukemia (T‐ALL).
Tra Ly Nguyen, Marie‐Julie Nokin, Silvia Terés, Mercedes Tomé, Clément Bodineau, Oriane Galmar, Jean‐Max Pasquet, Benoit Rousseau, Sebastian vanLiempd, Juan Manuel Falcon‐Perez, Elodie Richard, Elodie Muzotte, Hamid‐Reza Rezvani, Muriel Priault, Marion Bouchecareilh, Isabelle Redonnet‐Vernhet, Julien Calvo, Benjamin Uzan, Françoise Pflumio, Patricia Fuentes, Maria L. Toribio, Abdel‐Majid Khatib, Pierre Soubeyran, Piedad del Socorro Murdoch, Raúl V. Durán   +24 more
doaj   +1 more source

Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]

, 2016
BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen, Huang, Yi-Ching, Jao, Li-En, Jiang, Jie-Peng, Lai, Zih-Yin, Lin, Min-Hsuan, Liu, Lawrence Yu-Min   +6 more
core   +2 more sources

Molecular Characterization of Notch1 Positive Progenitor Cells in the Developing Retina. [PDF]

PLoS ONE, 2015
The oscillatory expression of Notch signaling in neural progenitors suggests that both repressors and activators of neural fate specification are expressed in the same progenitors.
Galina Dvoriantchikova, Isabel Perea-Martinez, Steve Pappas, Ariel Faye Barry, Dagmara Danek, Xenia Dvoriantchikova, Daniel Pelaez, Dmitry Ivanov   +7 more
doaj   +1 more source

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS [PDF]

, 2017
No abstract ...
A de Lourdes Perim, A Kumar, AM Gomez, AP Weng, BL Asselin, CH Pui, D Passaro, JL Cannon, K Letendre, M Thome, MP Felli, MT Williams, P Van Vlierberghe, S Buonamici, Y Ma   +14 more
core   +1 more source

Notch1 Is Involved in Physiologic Cardiac Hypertrophy of Mice via the p38 Signaling Pathway after Voluntary Running

International Journal of Molecular Sciences, 2023
Appropriate exercise such as voluntary wheel-running can induce physiological cardiac hypertrophy. Notch1 plays an important role in cardiac hypertrophy; however, the experimental results are inconsistent. In this experiment, we aimed to explore the role
Weiwei Zhang, Jiayi Liu, Zekang Wu, Guanwei Fan, Zhuo Yang, Chunhua Liu   +5 more
semanticscholar   +1 more source