Results 51 to 60 of about 2,402,104 (309)

Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis [PDF]

Gut, 2016
Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design Mice were treated with the pan-Notch inhibitor dibenzazepine (DBZ) or ...
Gail B, Gifford, Elise S, Demitrack, Theresa M, Keeley, Andrew, Tam, Nilsa, La Cunza, Priya H, Dedhia, Jason R, Spence, Diane M, Simeone, Ichiko, Saotome, Angeliki, Louvi, Christian W, Siebel, Linda C, Samuelson   +11 more
openaire   +2 more sources

A Novel PAK1–Notch1 Axis Regulates Crypt Homeostasis in Intestinal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine kinases and contributes to cellular pathways such as nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein ...
Adrian Frick, Vineeta Khare, Kristine Jimenez, Kyle Dammann, Michaela Lang, Anita Krnjic, Christina Gmainer, Maximilian Baumgartner, Ildiko Mesteri, Christoph Gasche   +9 more
doaj   +1 more source

In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. [PDF]

PLoS ONE, 2013
Mechanosensory hair cells (HCs) and surrounding supporting cells (SCs) in the mouse cochlea are important for hearing and are derived from the same prosensory progenitors.
Zhiyong Liu, Zhenyi Liu, Bradley J Walters, Thomas Owen, Raphael Kopan, Jian Zuo   +5 more
doaj   +1 more source

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas [PDF]

, 2011
Copyright © 2011 Cantilena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Cantilena, S, Chayka, O, Pastorino, F, Pezzolo, A, Pistoia, V, Ponzoni, M, Sala, A   +6 more
core   +2 more sources

A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

Cancer Cell International, 2018
Background Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies.
Yang Zheng, Zhao Wang, Xu Ding, Wei Zhang, Gang Li, Laikui Liu, Heming Wu, Wenyi Gu, Yunong Wu, Xiaomeng Song   +9 more
doaj   +1 more source

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. [PDF]

, 2013
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry.
Abdi, Khadar, Benner, Eric, Eroglu, Cagla, Jo, Rebecca, Kuo, Chay, Liu, Chunlei, Luciano, Dominic, Paez-Gonzalez, Patricia, Sheng, Huaxin, Warner, David   +9 more
core   +1 more source

Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer

Cell Communication and Signaling, 2019
Prostate cancer (PCa) is the second leading cause of mortality and a leading cause of malignant tumors in males. Prostate cancer stem cells (PCSCs) are likely the responsible cell types for cancer initiation, clinical treatment failure, tumor relapse ...
Yongmei Shen, Jiasong Cao, Zhixian Liang, Qimei Lin, Jianxi Wang, Xu Yang, Ran Zhang, Jiaojiao Zong, Xiaoling Du, Yanfei Peng, Ju Zhang, Jiandang Shi   +11 more
semanticscholar   +1 more source

Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer [PDF]

Cancer Science, 2012
Notch functions as an oncogene or tumor suppressor according to the type of malignancy, and the BRAFV600E mutation is commonly observed in thyroid cancer. However, the role of Notch and BRAFV600E in papillary thyroid cancer (PTC) is unclear. This study sought to elucidate the clinicopathological characteristics in patients with PTC regarding the ...
Hyung Seok, Park, Chan-Kwon, Jung, Sung Hak, Lee, Byung Joo, Chae, Dong Jun, Lim, Woo Chan, Park, Byung Joo, Song, Jeong Soo, Kim, Sang Seol, Jung, Ja-Seong, Bae   +9 more
openaire   +2 more sources

DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway

Cell Cycle, 2022
Breast carcinoma is one of the common causes of cancer-related mortality in women. Maternally expressed gene 3 (MEG3), a lncRNA located at 14q32, can be involved in carcinogenesis.
Tingting Pan, Haiwen Ding, Le Jin, Shaobo Zhang, Delin Wu, Wanwan Pan, M. Dong, Xiaopeng Ma, Zhaolin Chen   +8 more
semanticscholar   +1 more source

Down-Modulation of Notch1 Expression in Cervical Cancer Is Associated with HPV-Induced Carcinogenesis

Cancer Biology & Medicine, 2009
OBJECTIVE Notch1 signaling has been implicated in tumorigenesis. The purpose of this study was to investigate the putative role of the Notch1 receptor in carcinogenesis and in the progression of the cervical cancer.
Li SUN, Yongmei SONG, Tong TONG
doaj   +1 more source