Results 251 to 260 of about 410,064 (307)

Immune sentinel function of nasal mucosal epithelial cells in allergic rhinitis: a review on barrier damage and inflammatory amplification loops regulated by calcium signalling. [PDF]

Front Immunol
Liu Y, Sun Q, Meng C, Sha J, Zhu D, Wu N.   +5 more
europepmc   +1 more source

Disrupting melanin transfer: innovative strategy for anti-pigmentation drug discovery. [PDF]

J Enzyme Inhib Med Chem
Niu X, Zhi J, Feng M, Wang S, Feng X, Jiang X, Chen W, Bai R.   +7 more
europepmc   +1 more source

CHRNB4-Mediated Neuroactive Signaling Rewiring Drives Adaptive Resistance to BCL-2 Inhibition in Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Koyama H, Seo S, Tse W, Bian S, Liu S.
europepmc   +1 more source

Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD. [PDF]

Cancer Biol Ther
Xie Y, Wang J, Zhou J, Peng Y, Wang Y, Wang Y, Song Y.   +6 more
europepmc   +1 more source

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Cardiovascular Responses Mediated by Protease-Activated Receptor-2 (PAR-2) and Thrombin Receptor (PAR-1) are Distinguished in Mice Deficient in PAR-2 or PAR-1

Journal of Pharmacology and Experimental Therapeutics, 1999
We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-
Bruce P Damiano, Wai-Ping Fung-Leung, Richard D Ye   +2 more
exaly   +3 more sources

Thrombin receptor PAR-1 is a glial cell receptor involved in the regeneration of peripheral nerves

Italian Journal of Anatomy and Embryology, 2013
Thrombin, a multifunctional serine protease, is a key enzyme in the coagulation cascade. Most of its actions are mediated by a G protein-coupled protease activated receptor (PAR-1) which is highly expressed in glial cells especially after injury (Pompili et al., 2006; Pompili et al., 2011) .
FABRIZI, CINZIA, POMPILI, Elena, SOMMA, FRANCESCA, FUMAGALLI, Lorenzo   +3 more
openaire   +4 more sources

miR‐20b regulates expression of proteinase‐activated receptor‐1 (PAR‐1) thrombin receptor in melanoma cells

Pigment Cell & Melanoma Research, 2014
SummaryThe proteinase‐activated receptor 1 (PAR‐1) plays a central role in melanoma progression and its expression level is believed to correlate with the degree of cancer invasiveness. Here, we show that PAR‐1 is post‐transcriptionally regulated by miR‐20b microRNA in human melanoma cells.
Saleiban A, Faxälv L, Claesson K, Jönsson JI, Osman A   +4 more
openaire   +4 more sources

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

Journal of Molecular Histology, 2010
Proteinase activated receptors (PAR 1-4) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. To evaluate the significance of expression and co-expression of PAR in cancer we performed a survey on published data.
Petersen Iver
exaly   +3 more sources

Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents

Expert Opinion on Therapeutic Patents, 2006
In addition to its central role in haemostasis and wound healing, thrombin activates platelets and smooth muscle cells by proteolytic activation of cell surface protease-activated receptor-1 (PAR-1), which is also known as the thrombin receptor. Thrombin is the most potent activator of human platelets and, as such, a thrombin receptor antagonist is ...
Samuel, Chackalamannil, Yan, Xia
openaire   +2 more sources