Results 51 to 60 of about 410,064 (307)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman +7 more
wiley +1 more source
Radiolabelled GLP-1 receptor antagonist binds to GLP-1 receptor-expressing human tissues. [PDF]
, 2014 PURPOSE Radiolabelled glucagon-like peptide 1 (GLP-1) receptor agonists have recently been shown to successfully image benign insulinomas in patients.
Waser, Beatrice, Reubi, Jean-Claude
core +1 more source
Neural Plasticity, 2015 Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a role in varied forms of developmental and postnatal neuroplasticity. MMP substrates include protease-activated receptor-1 (PAR-1), a G-protein coupled receptor expressed in ...
Maria Maddalena Valente +5 more
doaj +1 more source
Zyxin is Involved in Thrombin Signaling via Interaction with PAR‐1 Receptor
The FASEB Journal, 2008 Thrombin‐induced increase in endothelial monolayer permeability depends on reorganization of the cytoskeletal structures. Protease‐activated receptor‐1 (PAR‐1) is the main receptor responsible for thrombin signaling in endothelial cells. Here we showed that PAR‐1 receptor interacted with zyxin, a LIM domain containing phosphoprotein, both in vitro and ...
Tatyana Voyno‐Yasenetskaya +1 more
openaire +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
wiley +1 more source
Frontiers in Pharmacology, 2017 Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To
Pengfei Zuo +6 more
doaj +1 more source
Receptor Dimerization with EPCR Redirects PAR‐1 Signaling in Endothelial Cells
The FASEB Journal, 2008 Activated protein C (APC) is the only therapeutic shown to reduce mortality in patients with severe sepsis, however its mechanism of action remains unknown. An important possibility is that APC influences the activation of the G‐protein coupled thrombin receptor (PAR‐1) in the endothelium to promote barrier function.
Joseph N McLaughlin, Asrar B Malik
openaire +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa +8 more
wiley +1 more source
Mecanismos envolvidos nas respostas nociceptivas e inflamatórias induzidas pela tripsina na pata de camundongos [PDF]
, 2007 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaAlém de funcionarem como enzimas de degradação, certas proteases atuam como moléculas de sinalização que regulam algumas ...
Paszcuk, Ana Flávia
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro +11 more
wiley +1 more source