Results 81 to 90 of about 53,843 (262)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance

Therapeutic Advances in Gastroenterology, 2017
Background: Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 ...
Michele Ammendola, Rosario Sacco, Giuseppina Vescio, Valeria Zuccalà, Maria Luposella, Rosa Patruno, Nicola Zizzo, Claudia Gadaleta, Ilaria Marech, Roberta Ruggieri, Ibrahim Furkan Kocak, Taner Ozgurtas, Cosmo Damiano Gadaleta, Giuseppe Sammarco, Girolamo Ranieri   +14 more
doaj   +1 more source

Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation

Respiratory Research, 2011
Background A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear.
Dienger Krista, Zhou Ping, Ledford John R, Day Scottie B, Lewkowich Ian P, Wills-Karp Marsha, Page Kristen   +6 more
doaj   +1 more source

Protease‐activated receptor 2 (PAR‐2) biased agonism in ovarian cancer progression

The FASEB Journal, 2019
Ovarian cancer is one of the most fatal gynecological malignancies due to its delayed clinical presentation, indicating a need to investigate molecular mechanisms of advanced disease. Dysregulated proteolysis contributes to crucial steps of ovarian cancer metastasis, including shedding and dissemination of cells to the peritoneal cavity.
Nisha R. Pawar, Nadire Duru, Gregory D. Conway, Toni M. Antalis   +3 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand

Platelets, 2017
Thrombin is the most potent agonist of human platelets and its effects are primarily mediated through the protease-activated receptors (PARs)-1 and -4.
I. C. Moschonas, T. F. Kellici, T. Mavromoustakos, P. Stathopoulos, V. Tsikaris, V. Magafa, A. G. Tzakos, A. D. Tselepis   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Research on Correlation Between Psychological Factors, Mast Cells, and PAR-2 Signal Pathway in Irritable Bowel syndrome

Journal of Inflammation Research, 2021
Guanqun Chao,1 Zhaojun Wang,2 Shuo Zhang3 1Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People’s Republic of China; 2The First Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou ...
Chao G, Wang Z, Zhang S
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source