Results 111 to 120 of about 23,240 (230)

The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats

Journal of Pharmacological Sciences, 2015
We investigated the anxiolytic effects and mechanism of action of a new anxiolytic drug, (R)-piperonyl-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridine-3- carboxamide hydrochloride (AP521).
Ken-ichi Kasahara, Shinji Hashimoto, Tsuyoshi Hattori, Koh Kawasaki, Ryuichi Tsujita, Osamu Nakazono, Katsuyuki Takao, Hiromu Kawakubo, Tadashi Nagatani   +8 more
doaj   +1 more source

Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats

Journal of Pharmacological Sciences, 2013
Electrophysiological studies were performed to determine whether serotonergic modulation in the nucleus accumbens (NAcc) was affected after repeated methamphetamine (MAP) administration. NAcc slices (400 μm) from Wistar rats administered MAP (5 mg/kg) or
Kumatoshi Ishihara, Naomichi Takahashi, Naoki Komoto, Chisato Yoshikawa, Shuhei Fukumoto, Soichiro Ide, Takeshi Kimura, Koichiro Ozawa   +7 more
doaj   +1 more source

Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress

Cell Reports, 2017
Summary: Transient reduced food intake (hypophagia) following high stress could have beneficial effects on longevity, but paradoxically, hypophagia can persist and become anorexia-like behavior.
Alexandra Jean, Laetitia Laurent, Sabira Delaunay, Stéphane Doly, Nicole Dusticier, David Linden, Rachael Neve, Luc Maroteaux, André Nieoullon, Valérie Compan   +9 more
doaj   +1 more source

In vivo serotonin 1A receptor distribution in treatment-resistant depression

Translational Psychiatry
Major depressive disorder (MDD) ranks among the leading causes of disability worldwide. An additional burden arises from treatment-resistance, defined by a lack of response to two or more adequate pharmacotherapeutic treatment trials.
Matej Murgaš, Christian Milz, Peter Stöhrmann, Jakob Unterholzner, Lukas Nics, Georg S. Kranz, Andreas Hahn, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger, Godber M. Godbersen   +10 more
doaj   +1 more source

[The involvement of 5-HT1a serotonin receptors in the pathophysiology and pharmacotherapy of schizophrenia].

Psychiatria polska, 2000
Many studies of schizophrenic brains indicate the dysfunction of dopamine and glutamate systems in the prefrontal and frontal cortex. It seems that better understanding of mechanisms regulating functions of these neuronal cortical systems could contribute to creation of new drugs acting in the cortex selectively.
M, Maćkowiak, A, Czyrak, K, Wedzony
openaire   +1 more source

Investigation of a role for noradrenaline in the neurochemical and behavioural effects of an established and putative target for antianxiety/antidepressant drugs: a microdialysis and behavioural study in rats and NK1 receptor knockout mice.

, 2005
The precise neurochemical effects of antidepressants that underlie their efficacy remain unclear. Many antidepressants modulate noradrenaline transmission in vivo.
Stewart, R.J.
core  

THE PSYCHOPHARMACOLOGY OF SEROTONIN

Psychiatry and Clinical Psychopharmacology, 2021
The present paper gives, after a short overview of the state of the art of the serotonergic system in the CNS, several examples of functional approaches to study the effects of 5-HT drugs.
Berend OLIVIER, R.v. OORSCHOT, I. van WIJNGAARDEN   +2 more
doaj  

Efeitos do bloqueio de receptores a1 do núcleo mediano da rafe sobre o comportamento alimentar e expressão da proteína Fos [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014A serotonina (5HT) é um neurotransmissor envolvido no controle da ingestão de ...
Silva, Eduardo Simão da
core  

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Noble, M., Drake-Holland, A.J., Belcher, P.R.   +2 more
core  

Serotonin 5-HT1A Receptors Modulate Hippocampal Reactivity to Afferent Stimulation

, 1997
Hippocampal dentate gyrus reactivity to perforant path (PP) stimulation in the anesthetized rat was enhanced after systemic administration of the serotonin-releasing drug fenfluramine (FFA).
M. Segal, Y. Levkovitz
core   +1 more source