The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression
CNS Drugs, 2023 Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority of patients and new approaches are urgently needed. A wealth of evidence implicates the serotonin 1A (5-HT1A) receptor in the pathophysiology of depression.
Alexander L. W. Smith +3 more
core +5 more sources
Pharmacologic MRI Brain Imaging Studies of Serotonin 5-HT<sub>1</sub> Receptor Agonists in Awake Mice. [PDF]
Pharmacol Res PerspectABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brems BM +5 more
europepmc +2 more sources
5-HT1A Receptor Function Makes Wound Healing a Happier Process [PDF]
Frontiers in Pharmacology, 2018 Skin wound healing is a multistage phenomenon that is regulated by cell–cell interplay and various factors. Endogenous serotonin is an important neurotransmitter and cytokine.
Alia Sadiq +18 more
doaj +2 more sources
Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT1A Receptor for Therapeutic Potential in Depression and Anxiety [PDF]
ResearchThe 5-HT1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), and 5-hydroxy-N,N,N-dimethyltryptamine—derived
Shu-jie Li +16 more
doaj +2 more sources
Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
Frontiers in Neuroscience, 2010 Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission.
Paul R Albert +2 more
exaly +3 more sources
Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A. [PDF]
Sci AdvActivation of the serotonin receptor 5-HT1A has been shown to regulate mood and cognition, making 5-HT1A an important target in the treatment of anxiety, depression, and psychosis. Although the receptor signals through inhibitory G proteins, more work is necessary to understand differences in transducer coupling and its relation to functional activity.
Warren AL +5 more
europepmc +3 more sources
Expression of the serotonin 1A receptor in the horse brain
Journal of Animal Reproduction and Biotechnology, 2023 Background: Serotonin receptors can be divided into seven different families with various subtypes. The serotonin 1A (5-HT1A) receptor is one of the most abundant subtypes in animal brains.
Yeonju Choi, Minjung Yoon
doaj +1 more source
Functional consequences of a rare human serotonergic 5-HT1A receptor variant
Frontiers in Pharmacology, 2023 Serotonin (5-HT) plays a central role in various brain functions via the activation of a family of receptors, most of them G protein coupled receptors (GPCRs).
Merav Tauber, Yair Ben-Chaim
doaj +1 more source
A physiologic role for serotonergic transmission in adult rat taste buds. [PDF]
PLoS ONE, 2014 Of the multiple neurotransmitters and neuropeptides expressed in the mammalian taste bud, serotonin remains both the most studied and least understood.
Luc Jaber +3 more
doaj +1 more source
PLoS ONE, 2021 Cestodes are platyhelminth parasites with a wide range of hosts that cause neglected diseases. Neurotransmitter signaling is of critical importance for these parasites which lack circulatory, respiratory and digestive systems.
Federico Camicia +9 more
doaj +2 more sources