Results 31 to 40 of about 23,240 (230)

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists [PDF]

, 2014
Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system.
Newman-Tancredi, Adrian, John M Bissonnette, Bissonnette, John, Ana P. Abdala, Ana Paula Abdala, John M. Bissonnette, Adrian eNewman-Tancredi, Adrian Newman-Tancredi, Abdala, Ana Paula   +8 more
core   +1 more source

Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

Journal of Pharmacological Sciences, 2018
We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats.
Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo   +8 more
doaj   +1 more source

Dual actions of 5‐MeO‐DIPT at the serotonin transporter and serotonin 5‐HT1A receptor in the mouse striatum and prefrontal cortex

Neuropsychopharmacology Reports, 2021
Aims 5‐Methoxy‐N,N‐diisopropyltryptamine (5‐MeO‐DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5‐MeO‐DIPT involve the serotonin transporter (SERT) and serotonin 5‐hydroxytryptamine‐
Yoko Hagino, Frank Scott Hall, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +4 more
doaj   +1 more source

Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly calliphora vicina [PDF]

, 2012
Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP3)/Ca2+ and cyclic adenosine 3′,5′-monophosphate (cAMP) signalling ...
Walz, Bernd, Bernd Walz, Baumann, Otto, Claudia Röser, Nadine Jordan (120821), Röser,C., Bernd Walz (48845), Wolfgang Blenau, Balfanz, Sabine, Otto Baumann (48844), Blenau, Wolfgang, Baumann, A., Sabine Balfanz (120824), Jordan, Nadine, Baumann, Arnd, Sabine Balfanz, Arnd Baumann, Blenau, Wolfgang (Dr.), Claudia Röser (120818), Wolfgang Blenau (120829), Nadine Jordan, Otto Baumann, Röser, Claudia, Arnd Baumann (120826)   +23 more
core   +1 more source

Hippocampal 5-HT1A receptor and spatial learning and memory

Frontiers in Pharmacology, 2015
Spatial cognition is fundamental for survival in the topographically complex environments inhabited by humans and other animals. The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5 ...
Yifat eGlikmann-Johnston, Yifat eGlikmann-Johnston, Michael Martin Saling, Michael Martin Saling, David C Reutens, Julie C Stout   +5 more
doaj   +1 more source

Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex

Molecular Brain, 2020
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety level.
Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyeler   +4 more
doaj   +1 more source

Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness

Molecular Brain, 2011
The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire ...
Albert Paul R, Le François Brice, Millar Anne M   +2 more
doaj   +1 more source

Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. [PDF]

PLoS ONE, 2014
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-HTT) and the serotonin-1A (5-HT1A) receptor.
Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberger   +11 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking [PDF]

, 2012
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established.
Fröhlich, M., Dityatev, A., Guseva, D., Gorinski, N., Renner, U., Doering, F., Ponimaskin, E.G., Richter, D.W., Ponimaskin, E., Döring, F., Niebert, M., Wischmeyer, E., Neher, E., Abdel-Galil, D., Froehlich, M., Zeug, A., Richter, D., Dityateva, G., Woehler, A.   +18 more
core   +2 more sources