Results 61 to 70 of about 1,312,828 (285)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Receptor-like kinase OsASLRK regulates methylglyoxal response and content in rice

Journal of Integrative Agriculture, 2021
Receptor-like kinases (RLKs) are essential for plant abiotic stress responses. Methylglyoxal (MG) is a cellular metabolite that is often considered to be a stress signal molecule.
LIN Fa-ming, Shen LI, Ke WANG, Hao-ran TIAN, Jun-feng GAO, Chang-qing DU   +5 more
doaj   +1 more source

Kaempferol attenuates liver fibrosis by inhibiting activin receptor–like kinase 5

Journal of Cellular and Molecular Medicine, 2019
Liver fibrosis is a common public health problem. Patients with liver fibrosis are more likely to develop cirrhosis, or hepatocellular carcinoma (HCC) as a more serious consequence.
T. Xu, Shan Huang, Qianrong Huang, Zhi-Yong Ming, Min Wang, Rongrui Li, Yinnong Zhao   +6 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. [PDF]

PLoS ONE, 2012
Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia (AML).
Julhash U Kazi, Lars Rönnstrand
doaj   +1 more source

The ELR-SOBIR1 Complex Functions as a Two-Component Receptor-Like Kinase to Mount Defense Against Phytophthora infestans.

Molecular Plant-Microbe Interactions, 2018
The ELICITIN RESPONSE protein (ELR) from Solanum microdontum can recognize INF1 elicitin of Phytophthora infestans and trigger defense responses. ELR is a receptor-like protein (RLP) that lacks a cytoplasmic signaling domain and is anticipated to require
E. Domazakis, D. Wouters, R. Visser, S. Kamoun, M. Joosten, V. Vleeshouwers   +5 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A rice Serine/Threonine receptor-like kinase regulates arbuscular mycorrhizal symbiosis at the peri-arbuscular membrane

Nature Communications, 2018
In terrestrial ecosystems most plant species live in mutualistic symbioses with nutrient-delivering arbuscular mycorrhizal (AM) fungi. Establishment of AM symbioses includes transient, intracellular formation of fungal feeding structures, the arbuscules.
R. Roth, M. Chiapello, Héctor Montero, P. Gehrig, Jonas Grossmann, K. O’Holleran, Denise Hartken, Fergus Walters, Shu-Yi Yang, S. Hillmer, K. Schumacher, S. Bowden, M. Craze, E. Wallington, A. Miyao, R. Sawers, E. Martinoia, U. Paszkowski   +17 more
semanticscholar   +1 more source

ABA perception is modulated by membrane receptor-like kinases

Journal of Experimental Botany, 2020
This article comments on: Shang Y, Yang D, Ha Y, Shin H-Y, Nam KH. 2020. RPK1 and BAK1 sequentially form complexes with OST1 to regulate ABA-induced stomatal closure. Journal of Experimental Botany 71, 1491–1502.
Konopka-Postupolska, Dorota, Dobrowolska, Grazyna   +1 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source