Results 91 to 100 of about 6,048,033 (361)
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Nature Communications, 2017 BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress.
Jinping Liu +6 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 One of the major hurdles for cancer immunotherapy is the host’s innate antiviral defense mechanisms. They include innate immune cells, such as natural killer (NK) cells and macrophages, which can be recruited within hours to the site of injection to ...
Xinping Fu +3 more
doaj +1 more source
cMet and fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells [PDF]
, 2005 Fas receptor is constitutively expressed on endothelial cells; however, these cells are highly resistant to Fas-mediated apoptosis. In this study, we examined death-inducing signaling complex (DISC) formation in endothelial cells after Fas receptor ...
Brady, H.J.M., Smyth, L.A.
core +1 more source
Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88) [PDF]
Journal of Biological Chemistry, 1999 Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second ...
Jörg Köhl +7 more
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin
Nature Communications, 2022 The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand ...
Ya Zhu +10 more
doaj +1 more source
Cell Reports, 2018 Summary: B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa.
Robbert Hoogeboom +6 more
doaj +1 more source
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. [PDF]
, 1984 The association between T3 and the T cell antigen receptor was examined using the T3 bearing T cell leukemic line Jurkat. A monoclonal antibody, C305, was produced, which reacted with idiotypic-like determinants expressed on Jurkat.
Stobo, JD, Weiss, A
core
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core +2 more sources