Results 101 to 110 of about 3,665,457 (317)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Stevenson, Emma, Nimmo, Myra, Cockburn, Emma, Stevenson, Emma J, Robson-Ansley, Paula, Walshe, Ian, Nimmo, Myra A   +6 more
core  

Plasmodium vivax in vitro continuous culture: the spoke in the wheel

Malaria Journal, 2018
Understanding the life cycle of Plasmodium vivax is fundamental for developing strategies aimed at controlling and eliminating this parasitic species.
Maritza Bermúdez, Darwin Andrés Moreno-Pérez, Gabriela Arévalo-Pinzón, Hernando Curtidor, Manuel Alfonso Patarroyo   +4 more
doaj   +1 more source

A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

Nature Communications, 2020
One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp 2)−H allylation and apply it to the modular synthesis ...
Lu Chen, Haitian Quan, Zhongliang Xu, Hao Wang, Yuanzhi Xia, Liguang Lou, Weibo Yang   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The ALK Receptor Family

, 2015
The leukocyte tyrosine kinase (LTK) and anaplastic lymphoma kinase (ALK) receptor tyrosine kinases (RTKs) define a subgroup of the insulin receptor superfamily.
Hallberg, Bengt,, Bengt Hallberg, Palmer, Ruth H.,, Ruth H. Palmer   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Increased soluble CD200 in serum of SLE patients does not reflect disease activity or affect CD200R1 function in T cells

Arthritis Research & Therapy
Background CD200 receptor 1 (CD200R) is an inhibitory immune receptor that is functionally altered in people with the interferonopathy systemic lupus erythematosus (SLE): soluble CD200 is increased in serum, and on monocytes CD200R stimulates ...
Ellen D. Kaan, Fabienne Verburg, Maarten Limper, Linde Meyaard, Michiel van der Vlist   +4 more
doaj   +1 more source

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

Nature Communications, 2016
Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of ...
Changsheng Du, Yanhui Duan, Wei Wei, Yingying Cai, Hui Chai, Jie Lv, Xiling Du, Jian Zhu, Xin Xie   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source