Results 91 to 100 of about 4,143,567 (308)

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Computational and Structural Biotechnology Journal, 2019
Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders.
Paula Santos-Otte, Hanne Leysen, Jaana van Gastel, Jhana O. Hendrickx, Bronwen Martin, Stuart Maudsley   +5 more
doaj   +1 more source

Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor [PDF]

, 2012
The capa peptide receptor, capaR (CG14575), is a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (capa-1 and -2). To date, the capa peptide family constitutes the only known nitridergic peptides in insects,
Julian A. T. Dow, Davies Shireen-A., Selim Terhzaz (173629), Pablo Cabrero (189088), Jonathan C Radford, Shireen-A Davies, Robben Joris H., Cabrero Pablo, Brian D Hudson, Terhzaz Selim, Brian D. Hudson (189093), Joris H. Robben (189090), Graeme Milligan (76078), Cabrero, P., Hudson, B.D., Pablo Cabrero, Shireen-A. Davies, Hudson Brian D., Graeme Milligan, Jonathan C. Radford, Robben, J.H., Selim Terhzaz, Milligan Graeme, Joris H. Robben, Dow, J.A., Dow, J.A.T., Shireen-A. Davies (189097), Brian D. Hudson, Julian A T Dow, Radford, J.C., Joris H Robben, Jonathan C. Radford (189091), Terhzaz, S., Dow Julian A. T., Julian A. T. Dow (173652), Radford Jonathan C., Milligan, G., Davies, S.A.   +37 more
core   +1 more source

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]

Journal of Lipid Research, 2009
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and ...
Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk   +19 more
doaj   +1 more source

Androgen Receptor

, 2018
The majority of physiological actions of testosterone and dihydrotestosterone are mediated by the androgen receptor, a member of the nuclear receptor superfamily, encoded as a single gene on the X-chromosome. Androgen receptor has four functional domains,
Smith, LB, McEwan, IJ, Lee B. Smith, Iain J. McEwan   +3 more
core   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Kasukawa, T, Himes, S Roy, Kawai, Jun, Waddell, Nic, Hayashizaki, Yoshihide, Kasukawa, Takeya, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +35 more
core   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Computational and Mathematical Modelling of the EGF Receptor System [PDF]

, 2008
This chapter gives an overview of computational and mathematical modelling of the EGF receptor system. It begins with a survey of motivations for producing such models, then describes the main approaches that are taken to carrying out such modelling, viz.
Emmet McIntyre, McIntyre, Emmet, Colin G. Johnson, William Gullick, Johnson, Colin G., Gullick, William J.   +5 more
core   +1 more source