Results 81 to 90 of about 5,438,451 (166)

Increased soluble CD200 in serum of SLE patients does not reflect disease activity or affect CD200R1 function in T cells

Arthritis Research & Therapy
Background CD200 receptor 1 (CD200R) is an inhibitory immune receptor that is functionally altered in people with the interferonopathy systemic lupus erythematosus (SLE): soluble CD200 is increased in serum, and on monocytes CD200R stimulates ...
Ellen D. Kaan, Fabienne Verburg, Maarten Limper, Linde Meyaard, Michiel van der Vlist   +4 more
doaj   +1 more source

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

Nature Communications, 2016
Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of ...
Changsheng Du, Yanhui Duan, Wei Wei, Yingying Cai, Hui Chai, Jie Lv, Xiling Du, Jian Zhu, Xin Xie   +8 more
doaj   +1 more source

Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands [PDF]

, 2015
Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic ...
Hansen, Anders Højgaard, Hudson, Brian D., MacKenzie, Amanda E., Milligan, Graeme, Pandey, Sunil K., Sergeev, Eugenia, Ulven, Trond   +6 more
core   +2 more sources

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +3 more sources

Seasonal impact of PM2.5 on pro-oncogenic drivers among participants of a thermal power plant in India

Scientific Reports
Molecular epidemiology targeting the impact of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) on pro-oncogenic signaling has been sparsely reported from the Indian industrial belt.
Sukanya Ghosh, Rupa Chaudhuri, Meghna Mukherjee, Lucas Henneman, Priyanka Saha, Anurima Samanta, Subhabrata Dey, Mita Ray Sengupta, Dona Sinha   +8 more
doaj   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

PancrESS – a meta-analysis resource for understanding cell-type specific expression in the human pancreas

BMC Genomics
Background The human pancreas is composed of specialized cell types producing hormones and enzymes critical to human health. These specialized functions are the result of cell type-specific transcriptional programs which manifest in cell-specific gene ...
David Sturgill, Li Wang, H. Efsun Arda
doaj   +1 more source

Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists

Cell Discovery, 2022
Hongmin Cai, Youwei Xu, Shimeng Guo, Xinheng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H. Eric Xu, Xin Xie, Yi Jiang   +12 more
doaj   +1 more source

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7

Nature Communications
Targeting the Frizzled family (FZD1-10) of WNT receptors pharmacologically has, despite substantial therapeutic potential, proven difficult. Given an almost complete lack of validated, effective small molecules targeting FZDs, no putative ligand binding ...
Magdalena M. Scharf, Julia Kinsolving, Lukas Grätz, Jan Hendrik Voss, David Carrasco-Busturia, Björn Forsberg, Peter Kolb, Gunnar Schulte   +7 more
doaj   +1 more source

A novel octopamine receptor with preferential expression in Drosophila mushroom bodies [PDF]

, 1998
Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative ...
Han, K-A, Millar, NS
core