Results 101 to 110 of about 3,521,155 (317)

Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists

Cell Discovery, 2022
Hongmin Cai, Youwei Xu, Shimeng Guo, Xinheng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H. Eric Xu, Xin Xie, Yi Jiang   +12 more
doaj   +1 more source

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7

Nature Communications
Targeting the Frizzled family (FZD1-10) of WNT receptors pharmacologically has, despite substantial therapeutic potential, proven difficult. Given an almost complete lack of validated, effective small molecules targeting FZDs, no putative ligand binding ...
Magdalena M. Scharf, Julia Kinsolving, Lukas Grätz, Jan Hendrik Voss, David Carrasco-Busturia, Björn Forsberg, Peter Kolb, Gunnar Schulte   +7 more
doaj   +1 more source

Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling [PDF]

, 2015
Päivi Pihlajamaa, Biswajyoti Sahu, Olli A. Jänne   +2 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor‐expressing cells: implications for its therapeutic action [PDF]

, 2011
Camila Marques-da-Silva, Mariana M. Chaves, Newton G. Castro, Robson Coutinho‐Silva, Marília Zaluar P. Guimarães   +4 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

VEGF, its receptors and the Tie receptors in recurrent miscarriage [PDF]

, 2000
Piia Vuorela, Olli Carpén, Maija Tulppala, Erja Halmesmäki   +3 more
openalex   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein-tyrosine Phosphatase α, RPTPα, Is a Helicobacter pylori VacA Receptor [PDF]

, 2003
Kinnosuke Yahiro, Akihiro Wada, Masaaki Nakayama, Takahiro Kimura, Ken-ichi Ogushi, Takuro Niidome, Haruhiko Aoyagi, K. Yoshino, Kazuyoshi Yonezawa, Joel Moss, Toshiya Hirayama   +10 more
openalex   +1 more source