Results 21 to 30 of about 6,186,932 (263)
Evaluation of a novel virtual screening strategy using receptor decoy binding sites [PDF]
, 2016 Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets.
Kukol, A. +3 more
core +2 more sources
The Scientific World JOURNAL, 2007 Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4and LXB4being the main components of this series. LXs are generated by cooperation between 5-lipoxygenase (LO) and 12- or 15-LO during cell-cell interactions or by single cell types. LX epimers at carbon 15, the
ROMANO, Mario +2 more
openaire +4 more sources
Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma [PDF]
, 2012 Background: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure.
Benz, Alexander +2 more
core +2 more sources
Structural insight into small molecule action on Frizzleds
Nature Communications, 2020 WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far.
Paweł Kozielewicz +9 more
doaj +1 more source
Effect of knocking down the insulin receptor on mouse rod responses. [PDF]
, 2015 Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L +3 more
core +3 more sources
Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A
Cell Discovery, 2022 5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. It is involved in nervous system regulation and an attractive target for the treatment of psychosis, depression, schizophrenia, and ...
Yangxia Tan +8 more
doaj +1 more source
British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
John A. Peters +2 more
openaire +4 more sources
Central Role of the EGF Receptor in Neurometabolic Aging
International Journal of Endocrinology, 2012 A strong connection between neuronal and metabolic health has been revealed in recent years. It appears that both normal and pathophysiological aging, as well as neurodegenerative disorders, are all profoundly influenced by this “neurometabolic ...
Sana Siddiqui +5 more
doaj +1 more source
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias [PDF]
, 2017 Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates.
Aoki, Junken +9 more
core +2 more sources
Nature Communications, 2017 The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein +4 more
doaj +1 more source