Results 31 to 40 of about 4,842,588 (336)

Cryo-EM structure of the human histamine H1 receptor/Gq complex

Nature Communications, 2021
Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown.
Ruixue Xia, Na Wang, Zhenmei Xu, Yang Lu, Jing Song, Anqi Zhang, Changyou Guo, Yuanzheng He   +7 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Funk, B., Hansmann, A., Kessler, U., Kiess, W., Kolb, H. J.   +5 more
core   +1 more source

NUCLEAR RECEPTORS [PDF]

British Journal of Pharmacology, 2007
ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
John A. Peters, S P H Alexander, Alistair Mathie   +2 more
openaire   +4 more sources

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Nature Communications, 2017
The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager   +4 more
doaj   +1 more source

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A

Cell Discovery, 2022
5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. It is involved in nervous system regulation and an attractive target for the treatment of psychosis, depression, schizophrenia, and ...
Yangxia Tan, Peiyu Xu, Sijie Huang, Gong Yang, Fulai Zhou, Xinheng He, Honglei Ma, H. Eric Xu, Yi Jiang   +8 more
doaj   +1 more source

EphA2 is a functional receptor for the growth factor progranulin. [PDF]

, 2016
Although the growth factor progranulin was discovered more than two decades ago, the functional receptor remains elusive. Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor
Ahmed, Al-Ayadhi, Andrea Morrione, Atul Goyal, Baker, Bateman, Bhandari, Bhandari, Bogan, Brantley, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Brantley-Sieders, Buraschi, Carrasquillo, Catherine Sharpe, Cenik, Chan, Chen, Cheng, Cruts, Cruts, Culouscou, Dave, Dunn, Duxbury, Elizabeth Natkanski, Farach-Carson, Ferluga, Gass, Ghidoni, Gijselinck, Giorgio, Goldoni, Gonzalez, Grindel, He, He, Hess, Hu, Huang, Iozzo, Iozzo, Jun, Kessenbrock, Kohlschütter, Kullander, Lema Tomé, Lemmon, Liliana Schaefer, Lord, Lord, Lovat, Margaryan, Matsubara, Merline, Miao, Minami, Misaki, Monami, Monami, Noberini, Nykjaer, Ogawa, Park, Parri, Petty, Prudencio, Renato V. Iozzo, Romanello, Serrero, Simone Buraschi, Sleegers, Smith, Song, Taddei, Tang, Tangkeangsirisin, Tanimoto, Tanimoto, Thomas Neill, Toh, Toh, Tolkatchev, Van Damme, Van Kampen, Wang, Wesa, Whitelock, Wienken, Wilusz, Wykosky, Wykosky, Xia, Xu, Xu, Yamaguchi, Yang, Zanocco-Marani, Zinchuk, Zoeller   +101 more
core   +2 more sources

Method for identification of condition-associated public antigen receptor sequences [PDF]

eLife 2018;7:e33050, 2017
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv   +1 more source

D3PM: a comprehensive database for protein motions ranging from residue to domain

BMC Bioinformatics, 2022
Background Knowledge of protein motions is significant to understand its functions. While currently available databases for protein motions are mostly focused on overall domain motions, little attention is paid on local residue motions.
Cheng Peng, Xinben Zhang, Zhijian Xu, Zhaoqiang Chen, Yanqing Yang, Tingting Cai, Weiliang Zhu   +6 more
doaj   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source