Results 161 to 170 of about 391,709 (316)

Evidence for M2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs. [PDF]

Invest Ophthalmol Vis Sci
Zhou H, Zhou G, Yang Q, Niu J, Wang R, Liu H, Hou S, Bi H, Liao X.   +8 more
europepmc   +1 more source

Simultaneous administration of thromboxane A2- and serotonin S2-receptor antagonists markedly enhances thrombolysis and prevents or delays reocclusion after tissue-type plasminogen activator in a canine model of coronary thrombosis.

, 1989
Paolo Golino, J H Ashton, J McNatt, Pia Glas-Greenwalt, S K Yao, R A O'Brien, L. Maximilian Buja, J. T. Willerson   +7 more
openalex   +1 more source

Comparison of levocabastine, a new selective H1‐receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen. [PDF]

, 1986
M Kolly, Alain Pécoud
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Cartilage-targeting exosomes for delivery of receptor antagonist of interleukin-1 in osteoarthritis treatment. [PDF]

Osteoarthritis Cartilage
Pathrikar TV, Baby HM, Hakim B, Zhang H, Millán Cotto HA, Kondiboyina V, Zhang C, Bajpayee AG.   +7 more
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Exploring the Potential of a P2X3 Receptor Antagonist: Gefapixant in the Management of Persistent Cough Associated with Interstitial Lung Disease. [PDF]

Medicina (Kaunas)
Takahashi T, Saito A, Yorozuya T, Nishikiori H, Kuronuma K, Chiba H.   +5 more
europepmc   +1 more source

Postischemic Administration of Idazoxan, an α-2 Adrenergic Receptor Antagonist, Decreases Neuronal Damage in the Rat Brain [PDF]

, 1989
Ingvar Gustafson, Yoshitoyo Miyauchi, Tadeusz Wieloch   +2 more
openalex   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Pharmacokinetics, Pharmacodynamic, Safety and Tolerability of Fazamorexant, a Novel Dual Orexin Receptor Antagonist: Report of the First-in-Human Study. [PDF]

Drug Des Devel Ther
Ni J, Jin L, Zhao D, Zhang W, Li B, Huang X, Hao X.   +6 more
europepmc   +1 more source