Results 191 to 200 of about 391,709 (316)

Safety, Tolerability, and Pharmacokinetics of Filapixant, a Highly Selective P2X3 Receptor Antagonist, in an Ascending-Single-Dose First-in-Human Study. [PDF]

Pharmaceuticals (Basel)
Francke K, Baumann S, Gashaw I, Klein S, Rohde B, Zolk O, Fischer OM, Friedrich C.   +7 more
europepmc   +1 more source

Morphologic response of endometrium to a progesterone receptor antagonist, RU486, in monkeys

, 1986
Marilyn J. Koering, David Healy, Gary D. Hodgen   +2 more
openalex   +1 more source

In vivo and in vitro activity of selective 5‐hydroxytryptamine₂ receptor antagonists [PDF]

, 1986
Sean Conolan, Michael J. Quinn, David A. Taylor   +2 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Steroidal Mineralocorticoid Receptor Antagonist Side Effects and Reasons for Discontinuation: A Patient Survey (RELICS-PS). [PDF]

Pragmat Obs Res
Richard EL, Stephenson JJ, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG.   +10 more
europepmc   +1 more source

Effects of histamine and its receptor antagonists on peritoneal permeability

, 1988
Avshalom Shostak, Eva Chakrabarti, Przemyslaw Hirszel, John F. Maher   +3 more
openalex   +1 more source

Concentration‐effect relationships with FM 24: a new long acting beta‐ adrenergic receptor antagonist. [PDF]

, 1983
C. T. Dollery, H. J. Dargie, J Sassard, G. Cuisinaud   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Tiotidine, a new long-acting histamine H2-receptor antagonist: Comparison with cimetidine

, 1981
Charles T. Richardson, Mark Feldman, Craig Brater, Jeanna Welborn   +3 more
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source