Results 201 to 210 of about 391,709 (316)

Correction: Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3. [PDF]

Stem Cell Res Ther
Song J, Han Y, Chen Y, Cheng L, Xiao J, Li A, Kong D, Jiang Y, Zheng C.   +8 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone. [PDF]

Int J Mol Sci
Narasimhappagari J, Liu L, Balasubramaniam M, Ayyadevara S, Aboud O, Griffin WST.   +5 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Reversal of morphine-induced respiratory depression with the µ₁-opioid receptor antagonist naloxonazine engenders excitation and instability of breathing. [PDF]

Am J Physiol Lung Cell Mol Physiol
Getsy PM, May W, Henderson F, Coffee GA, Baby SM, Hsieh YH, Lewis SJ.   +6 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD). [PDF]

ACS Omega
Ng RA, Barratt S, Parisian A, Palanisamy GS, Phukan S, Sun R, Robello B, Peña G, Sapugay J, Yeghikyan D, Wang C, Satish Kher S, Thangathirupathy S, Millikin R, Yu G, Watanabe T, Zhou F, Rich B, Duncan A, Andersen SE, Chawla R, Zak DR, Heerding DA, Hearn BR, Greene G, Harmon CL, Hodges-Gallagher L, Kushner PJ, Fanning SW, Myles DC.   +29 more
europepmc   +1 more source

Agonist versus antagonist binding to alpha-adrenergic receptors.

, 1980
Brian B. Hoffman, Thomas Michel, D. M. Kilpatrick, Robert J. Lefkowitz, Margaret E. M. Tolbert, H R Gilman, John N. Fain   +6 more
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source