Results 241 to 250 of about 713,346 (360)

Palonosetron, a 5-HT3 Receptor Antagonist, Induces G1 Cell Cycle Arrest and Autophagy in Gastric Cancer Cells. [PDF]

Int J Mol Sci
Yoo YC, Lin L, Lee S, Shin YR, Oh JE, Kim NY.   +5 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Free Fatty Acids Correlate with the Interleukin-1 β and Interleukin-1 Receptor Antagonist in the Early Subacute Phase of Stroke. [PDF]

Biomolecules
Kotlega D, Drozd A, Zembron-Lacny A, Morawin B, Ryterska K, Szczuko M.   +5 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

HJP 272, an endothelin receptor antagonist, and its role in cancer cell migration and invasion. [PDF]

Transl Oncol
Baig N, Chilamakuri R, Agarwal S, Muth A, Reznik SE.   +4 more
europepmc   +1 more source

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N -methyl- d -aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

, 2018
Magdalini Sachana, Alexandra Rolaki, Anna Bal‐Price   +2 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Deficiency of interleukin-1 receptor antagonist aggravates Citrobacter rodentium infection in mice. [PDF]

Immunohorizons
Yeoh BS, Saha P, Kushwaha V, Gohara AF, Vijay-Kumar M.   +4 more
europepmc   +1 more source

Identification of chemokine receptor CCR4 antagonist

, 2005
Ashok V. Purandare, Aiming Gao, Honghe Wan, John E. Somerville, Christine Burke, Carrie L. Seachord, Wayne Vaccaro, John Wityak, Michael A. Poss   +8 more
openalex   +1 more source