Results 281 to 290 of about 3,169,653 (411)

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

CYP2D6 genotype and associated 5-HT₃ receptor antagonist outcomes: A systematic review and meta-analysis. [PDF]

Clin Transl Sci
Moore C, Williams E, Dyas R, Halman A, Stenta T, Khatri D, Elliott DA, Lange PW, Caudle KE, Conyers R.   +9 more
europepmc   +1 more source

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Interleukin 1 Receptor Antagonist (IL-1ra) Production and Expression Dynamics in Mammary Glands After Lipopolysaccharide Infusion. [PDF]

Anim Sci J
Marufah NL, Nii T, Suzuki N, Jaisue J, Isobe N.   +4 more
europepmc   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

A comprehensive review of finerenone-a third-generation non-steroidal mineralocorticoid receptor antagonist. [PDF]

Front Cardiovasc Med
Zhai S, Ma B, Chen W, Zhao Q.
europepmc   +1 more source

Quantitation of Phototoxic Hyperemia and Permeability to Protein: II. Inihibition by Histamine (H1 and H2) Receptor Antagonists in Mouse Skin

, 1980
Lawrence W. Argenbright, P. Donald Forbes, Gwendolyn J. Stewart   +2 more
openalex   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

The leukotriene receptor antagonist montelukast as a potential therapeutic adjuvant in multiple sclerosis - a review. [PDF]

Front Pharmacol
Pietrantonio F, Serreqi A, Zerbe H, Svenningsson P, Aigner L.   +4 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source