Results 21 to 30 of about 2,562,602 (168)

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Journal of Experimental Medicine, 2016
Jang et al. show that eosinophils in the small intestine can suppress Th17 cell differentiation through the secretion of the IL-1 receptor antagonist.
R. Sugawara, Eun-Jung Lee, M. Jang, Eun-ji Jeun, Chun-Pyo Hong, Jung-Hwan Kim, Areum Park, C. H. Yun, Sung-Wook Hong, You-Me Kim, J. Seoh, YunJae Jung, C. Surh, Masayuki Miyasaka, Bo-Gie Yang, M. Jang   +15 more
semanticscholar   +1 more source

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Journal of Cerebral Blood Flow and Metabolism, 2015
Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in part,
S. Maysami, Raymond Wong, J. Pradillo, Á. Dénes, Hiramani Dhungana, T. Malm, J. Koistinaho, C. Orset, Mahbubur Rahman, M. Rubio, M. Schwaninger, D. Vivien, P. Bath, N. Rothwell, S. Allan   +14 more
semanticscholar   +1 more source

The inhibitory effect of type V transforming growth factor-β receptor antagonist on the proliferation of keloid fibroblasts by suppressing insulin-like growth factor-binding protein 3-interleukin-6 signaling

Dermatologica Sinica
Background: Hyperplasia of fibroblasts is critical in keloid pathogenesis. Insulin-like growth factor-binding protein 3 (IGFBP3) is an important factor in the regulation of cell growth and type V transforming growth factor-β receptor (TβR-V) is a ...
Boya Zhou, Xunxun Lin, Lingling Xia, Zhen Gao, Meihua Di, Xiaoli Wu, Wenbo Wang   +6 more
doaj   +1 more source

Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Journal of Pharmacological Sciences, 2015
The blockade of metabotropic glutamate 5 (mGlu5) receptor has been reported to exert antidepressant effects in several animal models. We previously reported that both ketamine and an mGlu5 receptor antagonist exerted an effect in a novelty-suppressed ...
Kenichi Fukumoto, Shigeyuki Chaki
doaj   +1 more source

Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Scientific Reports, 2022
Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow, Felisha Teja, Afrooz Sheikhi, Fernando G. Exposto, Peter Svensson, Brian E. Cairns   +5 more
doaj   +1 more source

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Nature, 2012
Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many undesirable side effects (sedation, apnoea and ...
A. Manglik, A. Kruse, T. S. Kobilka, Foon Sun Thian, J. M. Mathiesen, R. Sunahara, L. Pardo, W. Weis, B. Kobilka, S. Granier   +9 more
semanticscholar   +1 more source

High Dose of 3, 7-Dimethyl-1-Propargylxanthine Induces Cell Death in YM-1 and KYSE30 Cancer Cell Lines

Medical Laboratory Journal, 2022
Background and objectives: Activation of adenosine A2a receptor has been shown to induce the growth and metastasis of cancer cells. The role of this receptor in esophageal cancer has not yet been determined. The present study aimed to investigate effects
Parisa zeinali, marie saghaeian, Jahanbakhsh Asadi, Seyyed Mehdi Jafari   +3 more
doaj  

Lateral Habenula Regulates Cardiovascular Autonomic Responses via the Serotonergic System in Rats

Frontiers in Neuroscience, 2021
The lateral habenula (LHb) plays essential roles in behavioral responses to stressful events. Stress is tightly linked to autonomic responses such as cardiovascular responses, yet how the LHb regulates these responses is not well understood.
Tri Huu Doan, Tri Huu Doan, Tri Huu Doan, Yuma Sato, Yuma Sato, Masayuki Matsumoto, Masayuki Matsumoto, Tadachika Koganezawa, Tadachika Koganezawa   +8 more
doaj   +1 more source

Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors

Biomolecules & Biomedicine, 2017
Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Studies on lerimazoline are rare, and its pharmacological profile is not completely understood.
Eldina Rizvić, Goran Janković, Slađana Kostić-Rajačić, Miroslav M. Savić   +3 more
doaj   +1 more source

Efficacy and safety of riociguat in combination therapy for patients with pulmonary arterial hypertension (PATENT studies)

Pulmonary Circulation, 2020
Many patients with pulmonary arterial hypertension do not achieve treatment goals with monotherapy, and therefore combination therapy is becoming the standard of care.
Hossein-Ardeschir Ghofrani, Ekkehard Grünig, Pavel Jansa, David Langleben, Stephan Rosenkranz, Ioana R. Preston, Franck Rahaghi, Namita Sood, Dennis Busse, Christian Meier, Marc Humbert   +10 more
doaj   +1 more source