Results 311 to 320 of about 713,346 (360)
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Bradykinin receptor antagonists
Medicinal Research Reviews, 1990Bradykinin and its active metabolites are produced at the sites of their actions by kallikreins. They potently elicit a variety of biological effects: hypotension, bronchoconstriction, gut and uterine contraction, epithelial secretion in airway, gut, and exocrine glands, vascular permeability, pain, connective tissue proliferation, and eicosanoid ...
R M, Burch, S G, Farmer, L R, Steranka
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General Pharmacology: The Vascular System, 1998
1. The peptide hormone and neurotransmitter, cholecystokinin, is widely distributed throughout the gastrointestinal tract and central nervous system and mediates a diverse number of biological functions. 2. Two receptor subtypes, CCK-A and CCK-B, have been identified by both pharmacological characterization and molecular cloning.
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1. The peptide hormone and neurotransmitter, cholecystokinin, is widely distributed throughout the gastrointestinal tract and central nervous system and mediates a diverse number of biological functions. 2. Two receptor subtypes, CCK-A and CCK-B, have been identified by both pharmacological characterization and molecular cloning.
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American Journal of Health-System Pharmacy, 1978
The uses of the histamine H2 receptor antagonists (H2 antagonists) in the management of peptic ulcer disease and the Zollinger-Ellison syndrome are reviewed. Drugs included in the discussion are burimamide, metiamide and cimetidine. The secretion and the pharmacology of the H2 antagonists are described.
J K, Siepler +3 more
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The uses of the histamine H2 receptor antagonists (H2 antagonists) in the management of peptic ulcer disease and the Zollinger-Ellison syndrome are reviewed. Drugs included in the discussion are burimamide, metiamide and cimetidine. The secretion and the pharmacology of the H2 antagonists are described.
J K, Siepler +3 more
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Chemokine Receptor Antagonists
Medicinal Research Reviews, 2000Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. Chemokines appear to be involved in a variety of proinflammatory and autoimmune diseases and this makes them and their receptors very attractive ...
R, Horuk, H P, Ng
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Endothelin receptor antagonists
World Journal of Urology, 2005Hormone refractory prostate cancer remains true to its middle name: it is largely refractory to attempts to delay its progression. New targets and new therapies are demanded. Through a review of the available literature on endothelin and several preclinical observations, the endothelin axis has emerged as one such target.
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1988
It is clear that the regulation of calcium movement plays a pivotal role in the control of a multitude of cellular activities. A discussion of the function of intracellular calcium, and of the many processes that are believed to control the level of cytoplasmic calcium ions, is beyond the scope of this chapter, and the reader is referred to one of the ...
I J, Reynolds, S H, Snyder
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It is clear that the regulation of calcium movement plays a pivotal role in the control of a multitude of cellular activities. A discussion of the function of intracellular calcium, and of the many processes that are believed to control the level of cytoplasmic calcium ions, is beyond the scope of this chapter, and the reader is referred to one of the ...
I J, Reynolds, S H, Snyder
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Endothelin Receptor Antagonists
2013Three pathways have been identified in the pathogenesis of pulmonary arterial hypertension (PAH): the endothelin (ET), nitric oxide (NO) and prostacyclin pathways. These pathways represent the targets of approved PAH therapies and their discovery has facilitated significant progress in the understanding and treatment of PAH.
Martine, Clozel +2 more
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Urotensin-II Receptor Antagonists
Current Medicinal Chemistry, 2006Urotensin-II (U-II) is a "somatostatin-like" cyclic neuropeptide which was originally isolated from goby fish urophysis, and subsequently identified in other species, including man. The interest in human U-II (hU-II) has grown enormously in the last few years, following the identification of a specific human receptor (formerly identified as the GPR14 ...
CAROTENUTO, ALFONSO +3 more
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Growth Hormone Receptor Antagonists
Neuroendocrinology, 2006The currently available long-acting somatostatin analogs normalize serum growth hormone (GH) levels and insulin-like growth factor-I levels in approximately 60% of patients with acromegaly. The recently introduced GH receptor antagonist, pegvisomant, is able to normalize insulin-like growth factor-I levels in virtually all acromegalic subjects ...
van der Lely, AJ (Aart-Jan) +1 more
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Competitive AMPA Receptor Antagonists
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA +2 more
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