Results 321 to 330 of about 3,169,653 (411)

IL-1 receptor antagonist anakinra downregulates inflammatory cytokines during renal normothermic machine perfusion: Preliminary results. [PDF]

Artif Organs
Hosgood SA, Moore T, Walker A, Nicholson ML.   +3 more
europepmc   +1 more source

Ageism in Rheumatology: the Healthcare Professional's Perspective

Arthritis Care &Research, Accepted Article.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the healthcare professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact ...
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source

Population pharmacokinetic modeling of zavegepant, a calcitonin gene-related peptide receptor antagonist, in healthy adults and patients with migraine. [PDF]

CPT Pharmacometrics Syst Pharmacol
Comisar CM, Francis J, Hughes JH, Bhardwaj R, Bertz R, Liu J.   +5 more
europepmc   +1 more source

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats. [PDF]

J Clin Invest
Zhu X, Potterfield R, Gruber KA, Zhang E, Newton SD, Norgard MA, Levasseur PR, Bai P, Chen X, Gu Q, Grossberg AJ, Marks DL.   +11 more
europepmc   +1 more source

NMDA receptor antagonist high-frequency oscillations are transmitted via bottom-up feedforward processing. [PDF]

Sci Rep
Wróbel J, Średniawa W, Bramorska A, Dovgialo M, Wójcik DK, Hunt MJ.   +5 more
europepmc   +1 more source

Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial. [PDF]

Diabetes Care
Boeder SC, Thomas RL, Le Roux MJ, Giovannetti ER, Gregory JM, Pettus JH.   +5 more
europepmc   +1 more source

Non-steroidal mineralocorticoid receptor antagonist finerenone inhibits peritoneal fibrosis induced by high-glucose dialysate via regulating enhancer of zeste homolog 2 (EZH2) expression. [PDF]

Ren Fail
Chen D, Shu J, Zhang X, Wang S, Sun J, Chong N, Sun Z, Xu Y, Wang Q.   +8 more
europepmc   +1 more source

CB₁ Receptor Antagonist Selonabant (ANEB-001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial. [PDF]

Clin Pharmacol Ther
Gorbenko AA, Heuberger JAAC, Juachon M, Klaassen E, Tagen M, Lawler JF, Schneeberger D, Cundy KC, Klumpers LE, Groeneveld GJ.   +9 more
europepmc   +1 more source

Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist. [PDF]

Purinergic Signal
Nagel J, Törmäkangas O, Kuokkanen K, El-Tayeb A, Messinger J, Abdelrahman A, Bous C, Schiedel AC, Müller CE.   +8 more
europepmc   +1 more source