Results 361 to 370 of about 3,169,653 (411)
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General Pharmacology: The Vascular System, 1998
1. The peptide hormone and neurotransmitter, cholecystokinin, is widely distributed throughout the gastrointestinal tract and central nervous system and mediates a diverse number of biological functions. 2. Two receptor subtypes, CCK-A and CCK-B, have been identified by both pharmacological characterization and molecular cloning.
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1. The peptide hormone and neurotransmitter, cholecystokinin, is widely distributed throughout the gastrointestinal tract and central nervous system and mediates a diverse number of biological functions. 2. Two receptor subtypes, CCK-A and CCK-B, have been identified by both pharmacological characterization and molecular cloning.
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1988
It is clear that the regulation of calcium movement plays a pivotal role in the control of a multitude of cellular activities. A discussion of the function of intracellular calcium, and of the many processes that are believed to control the level of cytoplasmic calcium ions, is beyond the scope of this chapter, and the reader is referred to one of the ...
Ian J. Reynolds, Solomon H. Snyder
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It is clear that the regulation of calcium movement plays a pivotal role in the control of a multitude of cellular activities. A discussion of the function of intracellular calcium, and of the many processes that are believed to control the level of cytoplasmic calcium ions, is beyond the scope of this chapter, and the reader is referred to one of the ...
Ian J. Reynolds, Solomon H. Snyder
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Endothelin Receptor Antagonists
2013Three pathways have been identified in the pathogenesis of pulmonary arterial hypertension (PAH): the endothelin (ET), nitric oxide (NO) and prostacyclin pathways. These pathways represent the targets of approved PAH therapies and their discovery has facilitated significant progress in the understanding and treatment of PAH.
Alessandro Maresta +3 more
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ChemInform Abstract: Chemokine Receptor Antagonists
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Richard Horuk, Ng Howard P
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Urotensin-II Receptor Antagonists
Current Medicinal Chemistry, 2006Urotensin-II (U-II) is a "somatostatin-like" cyclic neuropeptide which was originally isolated from goby fish urophysis, and subsequently identified in other species, including man. The interest in human U-II (hU-II) has grown enormously in the last few years, following the identification of a specific human receptor (formerly identified as the GPR14 ...
CAROTENUTO, ALFONSO +3 more
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Interleukin-1 receptor antagonist: role in biology.
Annual Review of Immunology, 1998The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response.
W. Arend +3 more
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Expert Opinion on Therapeutic Patents, 1999
It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba +2 more
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It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba +2 more
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Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry, 2008This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
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ChemInform Abstract: D4 Receptors and Their Antagonists
ChemInform, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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lnterleukin-1 Receptor Antagonist
Critical Reviews™ in Immunology, 1995The interleukin-1 receptor antagonist (IL-1ra) is unusual in that it is the only known naturally occurring, cytokine receptor antagonist with no apparent agonist function. Over the last 5 years, since the cloning of the IL-1ra cDNA sequence, there has been intensive research on the genetics, regulation, and potential therapeutic value of this protein ...
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