Results 31 to 40 of about 713,346 (360)

The Role of Intraamygdaloid Oxytocin and D2 Dopamine Receptors in Reinforcement in the Valproate-Induced Autism Rat Model

Biomedicines, 2022
Background: autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting around 1 out of 68 children and its incidence shows an increasing tendency. There is currently no effective treatment for ASD.
Kristóf László, Dávid Vörös, Orsolya Kiss, Bettina Réka László, Tamás Ollmann, László Péczely, Kitti Mintál, Attila Tóth, Anita Kovács, Olga Zagoracz, Erika Kertes, Veronika Kállai, Beáta Berta, Zoltán Karádi, László Lénárd   +14 more
doaj   +1 more source

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]

, 2012
This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J., Kreutter, M., LaCourt, M., Mantsch, John R., Stroh, G., Vaughn, Linda K., Vranjkovic, Oliver   +6 more
core   +2 more sources

Cholecystokinin Receptor Antagonist Suppresses Melanoma Growth by Inducing Apoptosis of Tumor Cells

JID Innovations, 2022
Melanoma is a malignant skin tumor with high metastatic activity. Although melanoma has been well-studied, its cellular kinetics remain elusive. The cholecystokinin (CCK) receptor is expressed in various types of tumors because CCK promotes the survival ...
Atsuko Funakoshi, Tetsuya Honda, Taisuke Ito, Yoshiki Tokura   +3 more
doaj   +1 more source

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]

, 2006
We report a multiwavelength (X-ray, ultraviolet/optical/infrared, radio) analysis of the relativistic tidal disruption event candidate Sw J2058+05 from 3 months to 3 yr post-discovery in order to study its properties and compare its behavior with that of
Bower, Geoffrey C., Brown, Gregory C., Cenko, S. Bradley, Dolan, Stephen, Filippenko, Alexei V., Fruchter, Andrew S., Greiner, Jochen, Horesh, Assaf, Hounsell, Rebekah A., Levan, Andrew J., O'Brien, Paul T., Page, Kim L., Pasham, Dheeraj R., Rau, Arne, Tanvir, Nial R., Wiersema, Klaas   +15 more
core   +2 more sources

The inhibitory effect of type V transforming growth factor-β receptor antagonist on the proliferation of keloid fibroblasts by suppressing insulin-like growth factor-binding protein 3-interleukin-6 signaling

Dermatologica Sinica
Background: Hyperplasia of fibroblasts is critical in keloid pathogenesis. Insulin-like growth factor-binding protein 3 (IGFBP3) is an important factor in the regulation of cell growth and type V transforming growth factor-β receptor (TβR-V) is a ...
Boya Zhou, Xunxun Lin, Lingling Xia, Zhen Gao, Meihua Di, Xiaoli Wu, Wenbo Wang   +6 more
doaj   +1 more source

Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Journal of Pharmacological Sciences, 2015
The blockade of metabotropic glutamate 5 (mGlu5) receptor has been reported to exert antidepressant effects in several animal models. We previously reported that both ketamine and an mGlu5 receptor antagonist exerted an effect in a novelty-suppressed ...
Kenichi Fukumoto, Shigeyuki Chaki
doaj   +1 more source

Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]

, 2008
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins, Baik, Battisti, Battisti, Boileau, Cador, Chiang, Crabbe, Crawford, de Wit, Down, Fleckenstein, Gabbay, Glickstein, Hamamura, Jones, Kalivas, Kamens, Karler, Karper, Kelly, Kelly, Kilty, Kuczenski, Kuribara, Kuribara, Kuribara, McDougall, Neve, Palmer, Phillips, Phillips, Pierce, Robinson, Ron, Rubinstein, Sax, Schmauss, Shen, Tanabe, Ujike, Vezina, Vezina, Xu, Xu, Xu, Xu, Yates   +47 more
core   +1 more source

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release [PDF]

, 2007
We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL).
Craighead, Mark, Grassie, Morag, Harrison, Louse R., Lightman, Stafford L., MacSweeney, Cliona P., Spiga, Francesca, Thomson, Fiona .J., Wood, Susan A.   +7 more
core   +1 more source

Loperamide Inhibits Tachykinin NK3-Receptor-Triggered Serotonin Release Without Affecting NK2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa

Journal of Pharmacological Sciences, 2005
The effect of loperamide on tachykinin NK2- and NK3-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro. The selective tachykinin NK2-receptor agonist [β-Ala8]-neurokinin A4–10 (βAla-NKA) or the selective NK3-receptor ...
Shu-ichi Kojima, Masashi Ikeda, Yuichiro Kamikawa   +2 more
doaj   +1 more source