Results 331 to 340 of about 514,942 (384)

Vertebrate non‐receptor protein–tyrosine kinase families

Genes to Cells, 1996
Many non‐receptor protein–tyrosine kinases (PTKs) function as subunits of receptors, either receptors with or without intrinsic PTK catalytic activity of their own. There are currently at least 33 known vertebrate genes that encode non‐receptor PTKs.
Kellie Neet, Tony Hunter
openaire   +4 more sources

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

Annual Review of Immunology, 1994
Engagement of the T cell antigen receptor (TCR) by peptide antigen bound to the major histocompatibility complex (MHC) molecules initiates a biochemical cascade involving protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases). Recent biochemical and genetic evidence has implicated at least three cytoplasmic protein tyrosine kinases
Andrew C. Chan, Arthur Weiss, Dev M. Desai   +2 more
openaire   +4 more sources

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

Annual Review of Cell Biology, 1994
P van der Geer, Tony Hunter, Richard A. Lindberg   +2 more
openaire   +3 more sources

Conformationally Induced Off-On Cell Membrane Chemosensor Targeting Receptor Protein-Tyrosine Kinases for in Vivo and in Vitro Fluorescence Imaging of Cancers.

Journal of the American Chemical Society, 2018
Molecules capable of monitoring receptor protein-tyrosine kinase expression could potentially serve as useful tools for cancer diagnosis due to the overexpression of tyrosine kinases during tumor growth and metastasis.
Yang Jiao, Jiqiu Yin, Haiyang He, Xiaojun Peng, Qianmiao Gao, Chunying Duan   +5 more
semanticscholar   +1 more source

Membrane receptors with protein-tyrosine kinase activity

Biochimie, 1987
Protein-tyrosine kinase activities have appeared so far to be intrinsic for two classes of proteins: the transforming proteins of certain retroviral oncogenes and the membrane receptors for certain cellular growth factors. In this latter family, the protein-tyrosine kinase is activated upon binding of the growth factor to its receptor and ...
Edmond M. Chambaz, Jean-Jacques Feige
openaire   +2 more sources

src-related protein tyrosine kinases and their surface receptors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993
The CD4-p56lck and CD8-p56lck complexes have served as a paradym for an expanding number of interactions between src-family members (p56lck, p59fyn, p56lyn, p55blk) and surface receptors. These interactions implicate src-related kinases in the regulation of a variety of intracellular events, from lymphokine production and cytotoxicity to the expression
Telfer, Janice T., Rudd, C.E., Janssen, O., Prasad, K.V.S., Raab, M., Dasilva, A., Yamamoto, H.   +6 more
openaire   +2 more sources

B61 is a ligand for the ECK receptor protein-tyrosine kinase

Nature, 1994
A protein ligand for the ECK receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the receptor as an affinity reagent. Initially, concentrated cell culture supernatants were screened for receptor binding activity using immobilized ECK-X in a surface plasmon resonance detection system.
Gary M. Fox, Tony Hunter, Anne Colombero, Paige Holst, Timothy D. Bartley, Ming Zhang, Elsa Fernandez, Geraldine Trail, Andrew A. Welcher, Brenda Guthrie, Hsieng Sen Lu, Yosef Yarden, Robert J. Toso, Robin Elliott, Robert W. Hunt, Brian Varnum, Richard A. Lindberg, Vann P. Parker, James D. Skrine, William J. Boyle   +19 more
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Comparative characterization of receptor and non-receptor associated protein tyrosine kinases

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
By using poly(Glu: Tyr, 4:1) as an exogenous substrate, the characteristics of insulin receptor associated protein tyrosine kinase (PTK) from rabbit skeletal muscle has been compared with a growth factor-independent non-receptor PTK partially purified from rat lung particulate fraction.
Jean-Louis Chiasson, Ashok K. Srivastava
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Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases

1994
Maintenance of a satisfactory immune system requires the daily generation of millions of lymphocytes from immature progenitor cells that reside (in adult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow ...
Roger M. Perlmutter, Steven J. Anderson
openaire   +3 more sources

Protein tyrosine kinases in the initiation of antigen receptor signaling

Current Opinion in Immunology, 1995
Intracellular responses to antigen receptor engagement involve the activation of protein tyrosine kinases and the tyrosine phosphorylation of cellular proteins, including components of the antigen receptor. Phosphorylation of two tyrosine residues within an 18 amino acid segment of the cytoplasmic domain of antigen receptor subunits, and the subsequent
openaire   +3 more sources