Results 41 to 50 of about 156,578 (338)
Receptor protein tyrosine kinases in perinatal developing rat kidney
Kidney International, 1997 We have identified receptor protein tyrosine kinases (PTKs) that are expressed and/or activated during kidney development. mRNA from fetal rat kidneys in late gestation (embryonic day 21), was used to prepare a cDNA template for polymerase chain reaction amplification with primers based on conserved regions of PTKs, and products were subcloned and ...
Nohjin Kee +3 more
openaire +3 more sources
Current understanding of tyrosine kinase BMX in inflammation and its inhibitors
Burns & Trauma, 2014 Tec family kinases, which include tyrosine kinase expressed in hepatocellular carcinoma (TEC), Bruton's tyrosine kinase (BTK), interleukin (IL)-2-inducible T-cell kinase (ITK), tyrosine-protein kinase (TXK), and bone marrow tyrosine kinase on chromosome ...
Le Qiu, Fei Wang, Sheng Liu, Xu-Lin Chen
doaj +1 more source
Protein connectivity in chemotaxis receptor complexes [PDF]
, 2015 The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Interactions among receptors, which are predominantly clustered at the cell poles, are crucial to this ...
arxiv +1 more source
Homologous Control of Protein Signaling Networks [PDF]
Journal of Theoretical Biology 279 (2011) 29-43, 2010 In a previous paper we introduced a method called augmented sparse reconstruction (ASR) that identifies links among nodes of ordinary differential equation networks, given a small set of observed trajectories with various initial conditions. The main purpose of that technique was to reconstruct intracellular protein signaling networks. In this paper we
arxiv +1 more source
Peptide G-Protein-Coupled Receptors and ErbB Receptor Tyrosine Kinases in Cancer
Biology, 2023 The ErbB RTKs (EGFR, HER2, HER3, and HER4) have been well-studied in cancer. EGFR, HER2, and HER3 stimulate cancer proliferation, principally by activating the phosphatidylinositol-3-kinase and extracellular signal-regulated kinase (ERK) pathways ...
Terry W. Moody +2 more
doaj +1 more source
Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer [PDF]
BMC Molecular Biology, 2001 We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal tissue from the same patient.Quantitative RT-PCR analysis of the expression of the EphB4 gene has shown that its expression is increased in 82% of tumour samples when compared with the matched normal ...
Stephenson, S. +4 more
openaire +4 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Follicle-stimulating hormone receptor: Advances and remaining challenges [PDF]
In: Arun K. Shukla (ed.), dir., G Protein-Coupled Receptors:
Emerging Paradigms in Activation, Signaling and Regulation Part A (p. 1-58).
International Review of Cell and Molecular Biology, 338 (1\`ere ed.). USA :
Elsevier. 171 p. (2018), 2018 Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).
arxiv +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. [PDF]
PLoS ONE, 2012 Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Ana Tomasovic +2 more
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