Results 31 to 40 of about 3,793,046 (254)

Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells
Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
doaj   +1 more source

Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT

Molecules, 2010
Imaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease ...
Justin W. Hicks, Henry F. VanBrocklin, Alan A. Wilson, Sylvain Houle, Neil Vasdev   +4 more
doaj   +1 more source

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions.
Christopher E. Rudd, Christopher E. Rudd, Christopher E. Rudd   +2 more
doaj   +1 more source

MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers

Egyptian Journal of Medical Human Genetics, 2021
Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males.
Malihe Zangoue, Amir Sadra Zangouei, Majid Mojarrad, Meysam Moghbeli   +3 more
doaj   +1 more source

Molecular docking study of new sorafenib analogues as platelet-derived growth factor receptor inhibitors for the treatment of cancer

Journal of Pharmacy and Bioallied Sciences, 2023
Cancer is a disease triggered by an uncontrolled growth of a group of cells usually from a single cell. Chemotherapy is a common and systematic therapy that involves the use of anticancer drugs also known as chemotherapeutical agents to treat cancer ...
Marwan I Jihad, Monther F Mahdi
doaj   +1 more source

Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase [PDF]

Journal of Biological Chemistry, 1995
B61 was originally described as a novel secreted tumor necrosis factor-alpha-inducible gene product in endothelial cells (Holzman, L. B., Marks, R. M., and Dixit, V. M. (1990) Mol. Cell. Biol. 10, 5830-5838). It was recently discovered that soluble recombinant B61 could serve as a ligand for the Eck receptor protein-tyrosine kinase, a member of the Eph/
H, Shao, A, Pandey, K S, O'Shea, M, Seldin, V M, Dixit   +4 more
openaire   +2 more sources

Fluorescence fluctuation analysis of Arabidopsis thaliana somatic embryogenesis receptor-like kinase and brassinosteroid insensitive 1 receptor ologomerization. [PDF]

, 2008
Receptor kinases play a key role in the cellular perception of signals. To verify models for receptor activation through dimerization, an experimental system is required to determine the precise oligomerization status of proteins within living cells ...
Vries, S.C., de, Russinova, Eugenia, Visser, Antonie J.W.G., Shah, K., Vries, S.C., de Vries, Sacco C, Hink, M.A., de Vries, S.C., Shah, Khalid, Hink, Mark A, Visser, A.J.W.G., Russinova, E.T., Visser, Antonie JWG, Hink, Mark A., de Vries, Sacco C., Russinova, E.   +15 more
core   +1 more source

Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment [PDF]

Journal of Biochemistry, 2012
It is widely accepted that receptor protein-tyrosine kinases (RTKs) are activated upon dimerization by binding to their extracellular ligands. However, EGF receptor (EGFR) dimerization per se does not require ligand binding. Instead, its cytoplasmic kinase domains have to form characteristic head-to-tail asymmetric dimers to become active, where one ...
Yuji, Yamanashi, Tohru, Tezuka, Kazumasa, Yokoyama   +2 more
openaire   +2 more sources

Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling

Life Science Alliance, 2021
This study analyses the function of the protein tyrosine phosphatase 1B identifying its binding partners and dephosphorylation targets for modulating B cell antigen receptor signaling.
Jennifer J Schwarz, Lorenz Grundmann, Thomas Kokot, Kathrin Kläsener, Sandra Fotteler, David Medgyesi, Maja Köhn, Michael Reth, Bettina Warscheid   +8 more
doaj   +1 more source