Results 31 to 40 of about 180,957 (163)
Current understanding of tyrosine kinase BMX in inflammation and its inhibitors
Burns & Trauma, 2014 Tec family kinases, which include tyrosine kinase expressed in hepatocellular carcinoma (TEC), Bruton's tyrosine kinase (BTK), interleukin (IL)-2-inducible T-cell kinase (ITK), tyrosine-protein kinase (TXK), and bone marrow tyrosine kinase on chromosome ...
Le Qiu, Fei Wang, Sheng Liu, Xu-Lin Chen
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Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Nature Communications, 2022 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation.
Hailin Tu +4 more
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JAK inhibitors: a new choice for diabetes mellitus?
Diabetology & Metabolic SyndromeAltered tyrosine kinase signaling is associated with a variety of diseases. Tyrosine kinases can be classified into two groups: receptor type and nonreceptor type. Nonreceptor-type tyrosine kinases are subdivided into Janus kinases (JAKs), focal adhesion
Mengjun Zhou, Qi Shen, Bo Li
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Molecular Cancer, 2018 Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate group to tyrosine residues of target protein, thus transmitting signals from the cell surface to cytoplasmic proteins and the nucleus to regulate physiological ...
Kodappully S. Siveen +8 more
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Frontiers in Pharmacology, 2016 Tyrosine kinases (TKs) is a family of tyrosine protein kinases with important functions in the regulation of a broad variety of physiological cell processes.
Kai eQu +7 more
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Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [PDF]
PLoS ONE, 2012 Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies.
Stephen R Spindler +4 more
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Peptide G-Protein-Coupled Receptors and ErbB Receptor Tyrosine Kinases in Cancer
Biology, 2023 The ErbB RTKs (EGFR, HER2, HER3, and HER4) have been well-studied in cancer. EGFR, HER2, and HER3 stimulate cancer proliferation, principally by activating the phosphatidylinositol-3-kinase and extracellular signal-regulated kinase (ERK) pathways ...
Terry W. Moody +2 more
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Association of the erythropoietin receptor with protein tyrosine kinase activity. [PDF]
Proceedings of the National Academy of Sciences, 1992 We have examined the signal transduction mechanism of the hematopoietic growth factor erythropoietin (Epo). Epo stimulation of Ba/F3 cells transfected with the Epo receptor resulted in increases in tyrosine phosphorylation of proteins of 97, 75, and 55 kDa.
D, Linnekin +3 more
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Neural Plasticity, 2018 Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase (SOD1) has been demonstrated.
Cinzia Mallozzi +3 more
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Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
Cell Death Discovery, 2022 Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk ...
Zeyu Yin +8 more
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