Results 11 to 20 of about 181,056 (261)

Receptor Protein Tyrosine Kinases and Phosphatases

Cold Spring Harbor Symposia on Quantitative Biology, 1992
It is clear that the number of receptor PTKs and PTPs encoded by a typical vertebrate genome is rather large. Although the signal pathways activated by the receptor PTKs may in many cases be common, specificity is provided by the ligand-binding domain and the availability of ligand.
T, Hunter, R A, Lindberg, D S, Middlemas, S, Tracy, P, van der Geer   +4 more
openaire   +2 more sources

Tyrosine phosphorylation of the BRI1 receptor kinase occurs via a posttranslational modification and is activated by the juxtamembrane domain

Frontiers in Plant Science, 2012
In metazoans, receptor kinases control many essential processes related to growth and development and response to the environment. The receptor kinases in plants and animals are structurally similar but evolutionarily distinct and thus while most animal ...
Man-Ho eOh, Steven D. Clouse, Steven C. Huber, Steven C. Huber   +3 more
doaj   +1 more source

Grb2 binding induces phosphorylation-independent activation of Shp2

Communications Biology, 2021
Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of ...
Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury   +5 more
doaj   +1 more source

Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions

Cells, 2020
Helicobacter pylori, a stomach-colonizing Gram-negative bacterium, is the main etiological factor of various gastroduodenal diseases, including gastric adenocarcinoma. By establishing a life-long infection of the gastric mucosa, H.
Marina Leite, Miguel S. Marques, Joana Melo, Marta T. Pinto, Bruno Cavadas, Miguel Aroso, Maria Gomez-Lazaro, Raquel Seruca, Ceu Figueiredo   +8 more
doaj   +1 more source

Substrate Specificity of R3 Receptor-like Protein-tyrosine Phosphatase Subfamily toward Receptor Protein-tyrosine Kinases [PDF]

Journal of Biological Chemistry, 2013
Receptor-like protein-tyrosine phosphatases (RPTPs) are involved in various aspects of cellular functions, such as proliferation, differentiation, survival, migration, and metabolism. A small number of RPTPs have been reported to regulate activities of some cellular proteins including receptor protein-tyrosine kinases (RPTKs).
Juichi, Sakuraba, Takafumi, Shintani, Sachiko, Tani, Masaharu, Noda   +3 more
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Antigen receptor signaling: integration of protein tyrosine kinase functions [PDF]

Oncogene, 1998
Antigen receptors on T and B cells function to transduce signals leading to a variety of biologic responses minimally including antigen receptor editing, apoptotic death, developmental progression, cell activation, proliferation and survival. The response to antigen depends upon antigen affinity and valence, involvement of coreceptors in signaling and ...
I, Tamir, J C, Cambier
openaire   +2 more sources

The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation

Haematologica, 2009
Background Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRβ (TPβ, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRα (FPα ...
Federica Toffalini, Anders Kallin, Peter Vandenberghe, Pascal Pierre, Lucienne Michaux, Jan Cools, Jean-Baptiste Demoulin   +6 more
doaj   +1 more source

Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2021
Discoidin domain receptor tyrosine kinases (DDRs) are a class of receptor tyrosine kinases (RTKs), and their dysregulation is associated with multiple diseases (including cancer, chronic inflammatory conditions, and fibrosis).
Li Chen, Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang   +10 more
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Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.

PLoS ONE, 2023
Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein domains that are characteristically associated with metazoans. Strikingly, receptor tyrosine kinases,
Teena Bajaj, John Kuriyan, Christine L Gee   +2 more
doaj   +1 more source

Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase [PDF]

Journal of Biological Chemistry, 1995
B61 was originally described as a novel secreted tumor necrosis factor-alpha-inducible gene product in endothelial cells (Holzman, L. B., Marks, R. M., and Dixit, V. M. (1990) Mol. Cell. Biol. 10, 5830-5838). It was recently discovered that soluble recombinant B61 could serve as a ligand for the Eck receptor protein-tyrosine kinase, a member of the Eph/
H, Shao, A, Pandey, K S, O'Shea, M, Seldin, V M, Dixit   +4 more
openaire   +2 more sources