Results 51 to 60 of about 514,942 (384)

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src [PDF]

, 2007
The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
A Schambony, AJ Mikels, AR Afzal, Faraz Khosravi Mardakheh, GC Schwabe, H Hikasa, H van Bokhoven, I Oishi, I Oishi, J Billiard, J Liu, John K. Heath, JP Gorvel, K Alexandropoulos, Lee M. Wheldon, M Miaczynska, M Nishita, M Oldridge, M Sammar, MR Larsen, P Masiakowski, R Ishizawar, Richard Steinhardt, S Stricker, S Takeuchi, SA Beausoleil, Shiva Akbarzadeh, Sonia Talma, Steve M. M. Sweet, TM DeChiara, WC Forrester, Y Liu, Z Songyang   +32 more
core   +5 more sources

Protein tyrosine kinases couple the interleukin‐2 receptor to p21^ras

European Journal of Immunology, 1993
AbstractThe T cell growth factor interleukin‐2 (IL‐2) induces p21ras activation in T lymphocytes. We have previously shown that a protein kinase C (PKC)‐mediated pathway for p21ras regulation exists in T cells and that the IL‐2 receptor (IL‐2R) can couple to p21ras independently of the presence of the PKC pathway for p21ras regulation.
Izquierdo, Manuel, Cantrell, Doreen A.
openaire   +5 more sources

Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer [PDF]

BMC Molecular Biology, 2001
We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal tissue from the same patient.Quantitative RT-PCR analysis of the expression of the EphB4 gene has shown that its expression is increased in 82% of tumour samples when compared with the matched normal ...
Stephenson, S., Slomka, S., Douglas, E., Hewett, P., Hardingham, J.   +4 more
openaire   +4 more sources

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk [PDF]

, 2000
The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally and had no major phenotypic alterations of the immune ...
Baltimore, David, Ellmeier, Wilfried, Hatam, Farah, Jung, Steffen, Littman, Dan R., Mano, Hiroyuki, Sunshine, Mary Jean, Xu, Yang   +7 more
core   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [PDF]

PLoS ONE, 2012
Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies.
Stephen R Spindler, Rui Li, Joseph M Dhahbi, Amy Yamakawa, Frank Sauer   +4 more
doaj   +1 more source

Negative Regulation of Receptor Tyrosine Kinases by T-cell Protein Tyrosine Phosphatase [PDF]

, 2009
Protein tyrosine phosphorylation controls a wide array of cellular responses such as growth, migration, proliferation, differentiation, metabolism and cytoskeletal organisation.
Mattila, Elina
core  

Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]

, 2014
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen, Annabel Borg, Arighi, Artim, Chan, Chen, Chen, Chen, Coulpier, Cutillas, DiNitto, Endres, Furdui, Gibelin, Hubbard, Hubbard, Iván Plaza-Menacho, Judith Murray-Rust, Karin Barnouin, Kawamoto, Kerry Goodman, Knowles, Lew, Lougheed, McTigue, Mologni, Neil Q. McDonald, Phillip Knowles, Plaza Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Rubén J. Martínez-Torres, Santoro, Stamos, Steen, Stephane Mouilleron, Wiesner, Yun, Zhang   +40 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source