Results 61 to 70 of about 514,942 (384)

Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. [PDF]

PLoS ONE, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Ana Tomasovic, Stephanie Traub, Ritva Tikkanen   +2 more
doaj   +1 more source

Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]

, 2009
The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D, Cohen, MS, Gao, X, Patel, TB, Taunton, J   +4 more
core   +2 more sources

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases*

Journal of Biological Chemistry, 1997
Previous work has demonstrated that SLP-76, a Grb2-associated tyrosine-phosphorylated protein, augments Interleukin-2 promoter activity when overexpressed in the Jurkat T cell line.
M. Musci, L. Hendricks-Taylor, D. Motto, M. Paskind, J. Kamens, Christoph W. Turck, G. Koretzky   +6 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons

Frontiers in Cell and Developmental Biology, 2022
Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system.
Li-Min Mao, Nirav Mathur, Tayyibah Mahmood, Sri Rajan, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +6 more
doaj   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core  

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. [PDF]

, 2015
In vitro and in vivo imaging of protein tyrosine kinase activity requires minimally invasive, molecularly precise optical probes to provide spatiotemporal mechanistic information of dimerization and complex formation with downstream effectors. We present
Acevedo, Adams, Ali, Antczak, Bae, Beenken, Blind, Bradshaw, Bunney, Bunney, Carter, Eswarakumar, Farrar, Fegan, Follo, Freeman, Gavine, Goetz, Helsten, Koss, Lemmon, Liu, Luedtke, Martin, Maruyama, McCubrey, Mohammadi, Roberti, Spagnuolo, Spille, Tomlinson, Touat, Welm, Zegzouti   +33 more
core   +3 more sources

Signaling by insulin receptors and related protein tyrosine kinases

Biomedical Reviews, 1996
The insulin receptor is a member of the largely expanding family of plasma membrane receptors. In general, ligand binding induces receptor dimerization leading to activation and tyrosine phosphorylation of the cytoplasmic catalytic domain of the receptor.
D. Margriet Ouwens, J. Antonie Maassen
openaire   +3 more sources

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. [PDF]

Proceedings of the National Academy of Sciences, 1990
Activation of the T-cell antigen receptor (TCR) results in tyrosine phosphorylation of the TCR zeta chain and other intracellular substrates. Two other T-cell integral membrane proteins, CD4 and CD8, are associated with the protein-tyrosine kinase (PTK), lck.
Richard D. Klausner, Andrew F. Phillips, Lawrence E. Samelson, Elise T. Luong   +3 more
openaire   +3 more sources

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

Proceedings of the National Academy of Sciences of the United States of America, 1994
We evaluated in WEHI 231 B cells the time-dependent responses of Lyn, Blk, Btk, Syk, and three members of the Jak family of protein tyrosine kinases following antibody-mediated surface engagement of the B-cell antigen receptor.
S. J. Saouaf, S. Mahajan, R. Rowley, S. Kut, J. Fargnoli, A. Burkhardt, Satoshi TSUKADAt, Owen N. WITTEt, J. Bolen   +8 more
semanticscholar   +1 more source