Results 81 to 90 of about 514,942 (384)

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]

, 2009
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian, Alexandra Mazharian, Arias-Salgado, Arias-Salgado, Arthur Weiss, Asselin, Auger, Avecilla, Baker, Best, Best, Cheli, Choudhuri, Dhanjal, Dorahy, Dubois, Ezumi, Gibbins, Gibbins, Harper, Hermiston, Holsinger, Jenson Lim, Jing W. Zhu, Jocelyn M. Auger, Kalia, Kato, Klages, Kovalenko, Kralisz, Kristin N. Kornerup, Le Pera, Lin, Lin, Liu, Mangin, McCarty, McNeill, Michael G. Tomlinson, Minuz, Moarefi, Mocsai, Morton, Neena Kalia, Nonne, Obergfell, Palka, Park, Pasquet, Pasquet, Pasquet, Pearce, Poole, Quek, Senis, Snell, Somani, Sorby, Steve G. Thomas, Steve P. Watson, Stuart Ellison, Superti-Furga, Suzuki-Inoue, Suzuki-Inoue, Tarvinder Dhanjal, Tsuboi, Vandendries, Wagner, Watanabe, Watson, Wonerow, Woodside, Xu, Xu, Yamaguchi, Yan Zhao, Yotis A. Senis, Young, Zhang, Zhu   +79 more
core   +2 more sources

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor (*)

Journal of Biological Chemistry, 1995
The activation of Janus protein-tyrosine kinases (Jaks) and the subsequent phosphorylation and activation of latent signal transducers and activators of transcription (Stats) are common elements in signal transduction through the cytokine receptor ...
F. Quelle, W. Thierfelder, B. Witthuhn, B. Tang, S. Cohen, J. Ihle   +5 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation. [PDF]

, 1996
Agrin is thought to be the nerve-derived factor that initiates acetylcholine receptor (AChR) clustering at the developing neuromuscularjunction. We have investigated the signaling pathway in mouse C2 myotubes and report that agrin induces a rapid but ...
Deiner, M, Ferns, M, Hall, Z
core  

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. [PDF]

, 1995
Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70.
Gelfand, EW, Kadlecek, TA, Mazer, BD, Weinberg, K, Weiss, A   +4 more
core   +2 more sources

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that critically regulates the viability, proliferation, and differentiation of granulocytic precursors and the function of neutrophils by signaling through its receptor. Cloning of the human
S. Corey, A. Burkhardt, J. Bolen, R. Geahlen, L. Tkatch, D. Tweardy   +5 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.

PLoS ONE, 2014
Breast tumor kinase (BRK), also known as protein tyrosine kinase 6 (PTK6), is a non-receptor tyrosine kinase overexpressed in more that 60% of human breast carcinomas.
Sayem Miah, Raghuveera Kumar Goel, Chenlu Dai, Natasha Kalra, Erika Beaton-Brown, Edward T Bagu, Keith Bonham, Kiven E Lukong   +7 more
doaj   +1 more source

Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor α protein in MCF-7 cells require the CSK c-Src tyrosine kinase. [PDF]

PLoS ONE, 2013
Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antagonists ...
Wei-Lan Yeh, Keiko Shioda, Kathryn R Coser, Danielle Rivizzigno, Kristen R McSweeney, Toshi Shioda   +5 more
doaj   +1 more source

The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders

Frontiers in Cell and Developmental Biology, 2021
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has been implicated in Alzheimer’s disease (AD), the most common form of dementia, and many other neurological diseases. The protein level and activity of STEP have been
Yacoubou Abdoul Razak Mahaman, Yacoubou Abdoul Razak Mahaman, Fang Huang, Kidane Siele Embaye, Xiaochuan Wang, Xiaochuan Wang, Feiqi Zhu   +6 more
doaj   +1 more source