Results 101 to 110 of about 940,834 (307)

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]

, 1999
Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G., Dieterle, C., Greulich, K. M., Krähn, Gertraud, Peter, R. U., Wolff, H.   +5 more
core   +1 more source

AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.

Cancer Research, 2012
The fibroblast growth factor (FGF) signaling axis is increasingly implicated in tumorigenesis and chemoresistance. Several small-molecule FGF receptor (FGFR) kinase inhibitors are currently in clinical development; however, the predominant activity of ...
P. Gavine, L. Mooney, E. Kilgour, Andrew P Thomas, Katherine Al-Kadhimi, Sarah Beck, C. Rooney, T. Coleman, D. Baker, M. Mellor, A. Brooks, T. Klinowska   +11 more
semanticscholar   +1 more source

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

Proceedings of the National Academy of Sciences of the United States of America, 2012
We assessed somatic alleles of six receptor tyrosine kinase genes mutated in lung adenocarcinoma for oncogenic activity. Five of these genes failed to score in transformation assays; however, novel recurring extracellular domain mutations of the receptor
H. Greulich, Bethany Kaplan, Philipp Mertins, Tzu-Hsiu Chen, K. Tanaka, C. Yun, Xiaohong Zhang, Se-Hoon Lee, Jeonghee Cho, L. Ambrogio, Rachel Liao, M. Imieliński, S. Banerji, A. Berger, M. Lawrence, Jinghui Zhang, Nam Pho, Sarah R Walker, W. Winckler, G. Getz, D. Frank, W. Hahn, M. Eck, D. Mani, Jacob D. Jaffe, S. Carr, Kwok-kin Wong, M. Meyerson   +27 more
semanticscholar   +1 more source

Fyn-Mediated Regulation of Protein Kinase A [PDF]

, 2017
Protein kinases are enzymes important for signal transduction in the regulation of cellular processes. The cAMP-dependent protein kinase A (PKA) has been previously reported to regulate the activity of the Src family kinase Fyn, an event important for ...
Barritt, Sam
core   +1 more source

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

Nature Network Boston, 2012
Although the treatment of acute myeloid leukemia (AML) has improved substantially in the past three decades, more than half of all patients develop disease that is refractory to intensive chemotherapy.
A. Kentsis, C. Reed, K. Rice, T. Sanda, S. Rodig, Eleni Tholouli, A. Christie, P. Valk, R. Delwel, V. Ngo, J. Kutok, S. Dahlberg, L. Moreau, R. Byers, J. Christensen, G. Woude, J. Licht, A. Kung, L. Staudt, A. Look   +19 more
semanticscholar   +1 more source

Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

Cell Reports, 2018
Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK ...
Tanveer S. Batth, Moreno Papetti, Anamarija Pfeiffer, Maxim A.X. Tollenaere, Chiara Francavilla, Jesper V. Olsen   +5 more
doaj   +1 more source

Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]

, 1997
The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core  

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus [PDF]

, 1989
Joachim Wittbrodt, Dieter Adam, Barbara Malitschek, Winfried Mäueler, Friedrich Raulf, Agnes Telling, Scott Robertson, Manfred Schartl   +7 more
openalex   +1 more source

“Liquid elbows” due to afatinib administration

Respiratory Medicine Case Reports, 2017
Non-small cell lung cancer adenocarcinoma in the past decade has targeted therapies as the cornerstone for therapy. In specific patients with epidermal growth factor receptor mutation have three different therapy approaches with the tyrosine kinase ...
Paul Zarogoulidis, Panos Chinelis, Anastasia Athanasiadou, Konstantinos Porpodis, Anastasios Kallianos, Aggeliki Rapti, Georgia Trakada, Lemonia Velentza, Haidong Huang, Theodora Tsiouda, Wolfgang Hohenforst-Schmidt   +10 more
doaj   +1 more source