Results 121 to 130 of about 940,834 (307)

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.

Cancer Research, 2006
K. O'reilly, F. Rojo, Q. She, D. Solit, G. Mills, Debra L. Smith, H. Lane, F. Hofmann, D. Hicklin, D. Ludwig, J. Baselga, N. Rosen   +11 more
semanticscholar   +1 more source

FLT3 Mutation as a Significant Prognostic Marker in de novo Acute Myeloid Leukemia Patients: Incidence, Distribution and Association with Cytogenetic Findings in a Study from South India

Middle East Journal of Cancer, 2014
Background: Fms-like tyrosine kinase 3 is a tyrosine kinase receptor that plays an important role in proliferation and differentiation of hematopoietic stem cells. Internal tandem duplication and tyrosine kinase domain mutation are the two most common
Santhi Sarojam, Sangeetha Vijay, Sureshkumar Raveendran, Jayadevan Sreedharan, Geetha Narayanan, Hariharan Sreedharan   +5 more
doaj  

Structural analysis of receptor tyrosine kinases

Progress in Biophysics and Molecular Biology, 1999
Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma-phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and ...
openaire   +3 more sources

Receptor Tyrosine Kinase

Definitions, 2020

semanticscholar   +1 more source

An Extracellular Domain of the Insulin Receptor β-Subunit with Regulatory Function on Protein-Tyrosine Kinase

, 1989
Roberto Gherzi, Giorgio Sesti, G. Andraghetti, Roberto De Pirro, Roberto Di Lauro, L Adezati, Renzo Cordera   +6 more
openalex   +1 more source

Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.

, 1987
Robert Ballotti, Finn Cilius Nielsen, Nigel P. Pringle, Aline Kowalski, William D. Richardson, Ellen Van Obberghen‐Schilling, Steen Gammeltoft   +6 more
openalex   +1 more source

Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence [version 3; peer review: 2 approved]

F1000Research
Tyrosine-protein kinase SYK, encoded by the SYK gene, is a non-receptor type protein kinase which mediates immune signal transduction through immunoreceptors.
Carl Laflamme, Kathleen Southern, Riham Ayoubi, Walaa Alshafie, Maryam Fotouhi   +4 more
doaj   +1 more source

Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With EGFR-Mutant Advanced Non–Small Cell Lung Cancer

JAMA Oncology, 2018
Shaodong Hong, Fangfang Gao, Sha Fu, Yan Wang, W. Fang, Yan Huang, Li Zhang   +6 more
semanticscholar   +1 more source

Production of Inhibitor of Insulin-Receptor Tyrosine Kinase in Fibroblasts From Patient With Insulin Resistance and NIDDM [PDF]

, 1991
Paolo Sbraccia, Patricia A. Goodman, Betty A. Maddux, Kwok-Ying Wong, Y-D.I. Chen, Gerald M. Reaven, Ira D. Goldfine   +6 more
openalex   +1 more source

JAK inhibitors: a new choice for diabetes mellitus?

Diabetology & Metabolic Syndrome
Altered tyrosine kinase signaling is associated with a variety of diseases. Tyrosine kinases can be classified into two groups: receptor type and nonreceptor type. Nonreceptor-type tyrosine kinases are subdivided into Janus kinases (JAKs), focal adhesion
Mengjun Zhou, Qi Shen, Bo Li
doaj   +1 more source