Results 41 to 50 of about 940,834 (307)

Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells

Drug Design, Development and Therapy, 2016
c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers.
Maryam Abbaspour Babaei, Behnam Kamalidehghan, M. Saleem, H. Huri, F. Ahmadipour   +4 more
semanticscholar   +1 more source

Late Effects of Disturbed IGF Signaling in Congenital Diseases. [PDF]

, 2007
The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specific cell surface receptors. IGF-1 binding to the extracellular -subunits activates the tyrosine kinase intrinsic to the cytoplasmic portion of the IGF-1 receptor ...
Cianfarani S, Geremia C, Germani D, Maiorana A, Puglianiello A   +4 more
core   +1 more source

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source

AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling

Cell Communication and Signaling, 2023
Background Gonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and non-reproductive cancers.
Pardis Mohammadzadeh, Mina Roueinfar, Gregory C. Amberg   +2 more
doaj   +1 more source

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia [PDF]

, 2014
Bruton's tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signalling downstream of a number of receptors.
Advani, Alam, Ashino, Baba, Bendall, Billottet, Burger, Burger, Byrd, Chang, Cordle, Dasmahapatra, David J. MacEwan, de Weers, Dos Santos, Doyle, Fiedler, Gallay, Grandage, Gu, Guzman, Hahn, Herman, Herrmann, Honda, Honigberg, Horwood, Ishii, Juliusson, Kawakami, Kim, Kojima, Kristian M. Bowles, Kvinlaug, Lyubov Zaitseva, Megan Y. Murray, Min, Mohamed, Nanri, Park, Quek, Renneville, Rushworth, Rushworth, Rushworth, Shinners, Sivina, Spiekermann, Stuart A. Rushworth, Sujobert, Tai, Tamburini, Tomasson, Tsukada, Vellenga, Venkataraman, Vetrie, Welch, Westermann, Zaitseva   +59 more
core   +1 more source

The Receptor Tyrosine Kinase AXL in Cancer Progression

Cancers, 2016
The AXL receptor tyrosine kinase (AXL) has emerged as a promising therapeutic target for cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor proliferation, survival, stem cell phenotype, metastasis, and resistance to ...
Erinn B. Rankin, A. Giaccia
semanticscholar   +1 more source

Exploring receptor tyrosine kinases-inhibitors in Cancer treatments

Egyptian Journal of Medical Human Genetics, 2019
Background Receptor tyrosine kinases (RTKs) are signaling enzymes responsible for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues substrates.
D. Samuel Metibemu, O. Adeboye Akinloye, A. Jamiu Akamo, D. Ajiboye Ojo, O. Tolulope Okeowo, I. Olaposi Omotuyi   +5 more
doaj   +1 more source

The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway

Translational Neuroscience, 2023
The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor ...
Kuang Guiying, Shu Zhigang, Zhu Chunli, Li Hongbing, Zhang Cheng   +4 more
doaj   +1 more source

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
core   +2 more sources

MicroRNA-208b inhibits human osteosarcoma progression by targeting ROR2

Tumor Biology, 2017
MicroRNAs are widely involved in cancer progression by inhibiting the expression levels of oncogenes or tumor suppressor genes, and dysregulation of microRNAs may contribute to tumorigenesis.
Zhe Jiang, Chunshan Jiang, Chonglong Yu, Jinnv Fang   +3 more
doaj   +1 more source