Results 191 to 200 of about 29,601 (261)

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Gestational diabetes mellitus-induced adipokine dysregulation and links to metabolic programming risks. [PDF]

Front Endocrinol (Lausanne)
Lis-Kuberka J, Berghausen-Mazur M.
europepmc   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source

T‑cadherin and its impact on human diseases (Review). [PDF]

Mol Med Rep
Song Y, Wang X, Bian Y.
europepmc   +1 more source

Adiponectin Receptor Protein 1 [PDF]

, 2020
openaire   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

The Hidden Metabolic Roots of Epilepsy. [PDF]

Biomedicines
Rubio C, Carpinteyro S, Serrano-García N, Romo-Parra H, Pérez-Villavicencio J, Lee Á, Mercado-Pimentel R, Rubio-Osornio M.   +7 more
europepmc   +1 more source

A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Aging is a systems‐level process linking metabolic dysfunction, inflammation, impaired repair, frailty, and multimorbidity, whereas existing pharmacological strategies usually optimize disease‐specific endpoints such as weight loss or HbA1c rather than aging‐related trajectories. We developed an SBML‐compliant quantitative systems pharmacology
Igor Goryanin, Bob Damms, Irina Goryanin
wiley   +1 more source

Insight to Neglected Biomarkers in COVID-19: A Comprehensive Narrative Review". [PDF]

Biomark Insights
Jalilian S, Bastani MN, Afsharzadeh F.
europepmc   +1 more source

A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies

Addiction, Volume 121, Issue 8, Page 1998-2018, August 2026.
Abstract Background and aims Evidence on the causal impact and corresponding risk relationships between dimensions of alcohol consumption and health outcomes continues to evolve, with some contradictory findings across study designs. This review aimed to update current knowledge on causality and risk relationships to inform global and national ...
Sinclair Carr, Ana Lucia Espinosa Dice, Gerhard E. Gmel Sr., Ahmed S. Hassan, Kevin D. Shield, Jürgen Rehm   +5 more
wiley   +1 more source