Results 211 to 220 of about 29,601 (261)

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction. [PDF]

PLoS Biol
Ikushima YM, Chen KC, Sulston RJ, Mattiucci D, Brain EJ, Fung Xin Zi SA, Suchacki KJ, Thomas BJ, Lovdel A, Bennett M, Kobayashi H, Whitfield PD, Takubo K, Baker AH, Morton NM, Semple RK, Cawthorn WP.   +16 more
europepmc   +1 more source

Centriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The identification of a patient carrying a novel homozygous p.(Gln206Ter) POC5 variant revealed a metabolic phenotype associated with POC5 deficiency. POC5 deficiency disrupts centriolar architecture and ciliary organization, leading to impaired proliferation, premature cellular senescence, and reduced insulin signaling.
Valeria Pistorio, Camille Vatier, Émilie Capel, Carine Beaupère, Martine Auclair, Virginie Steunou, Romain Morichon, Michael Joubert, Corinne Vigouroux, Jérémie Gautheron, Isabelle Jéru   +10 more
wiley   +1 more source

Tumor derived adiponectin induces immunosuppressive macrophages in upper tract urothelial carcinoma. [PDF]

Transl Oncol
Shen CH, Chen P, Chang CB, Chang CC, Wang M, Chou LP, Lai YY, Lee MY, Wu SF.   +8 more
europepmc   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology. [PDF]

Front Immunol
Chen S, Liu H, Wang K, Wang H, Xu A, Suo M, Chen X, Li Z.   +7 more
europepmc   +1 more source

From Fat to Brain: Adiponectin as a Mediator of Neuroplasticity in Depression. [PDF]

Biomolecules
Genini P, D'Aprile I, Petrillo G, Di Benedetto MG, Begni V, Cattane N, Cattaneo A.   +6 more
europepmc   +1 more source

Enzyme-Activated Self-Assembling Peptides Mimicking Adiponectin Multimers for Nonalcoholic Fatty Liver Disease Therapy. [PDF]

ACS Cent Sci
Li Z, Duan S, Zhu Z, Han H, Qin N, Ji Q, Yuan D, Shi J.   +7 more
europepmc   +1 more source

Evaluation of Serum Adipocytokines and Cystatin C As Early Biomarkers in Chronic Kidney Disease Patients and Their Relation to Endothelial Dysfunction. [PDF]

Cureus
Bagewadi HG, Patil S, Sugoor M, Melkundi RS, A S, Kallur R, Tondare SB.   +6 more
europepmc   +1 more source

Editorial for the Special Issue: Recent Advances in Adipokines-2nd Edition. [PDF]

Biomedicines
Buechler C.
europepmc   +1 more source