Results 181 to 190 of about 248,286 (331)

Retrospective evaluation of the impact of atropine administration on incidence of post‐operative colic in healthy, isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background In anaesthetised horses, bradycardia secondary to high vagal tone can reduce cardiac output and blood pressure. The use of anticholinergics in horses is limited due to concerns about ileus and abdominal discomfort. This retrospective study sought to determine the prevalence of post‐operative abdominal discomfort in healthy horses ...
Kelley M. Varner, Alexandra L. Curtiss, Patricia M. Hogan, Kim Love, John R. Dodam   +4 more
wiley   +1 more source

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg, JoAnn Slack, Darko Stefanovski, DeAnna Theiss, Klaus Hopster   +4 more
wiley   +1 more source

Effects of vatinoxan on gastrointestinal motility, sedation, and antinociception during and after long‐lasting detomidine infusion in horses

Equine Veterinary Journal, EarlyView.
Abstract Background Sedation in horses is typically achieved using alpha‐2 adrenoceptor agonists, although their use is associated with multiple side effects. A peripheral alpha‐2 adrenoceptor antagonist, vatinoxan, can alleviate many of these. Objectives To evaluate the effects of vatinoxan infusion on gastrointestinal motility, sedation, and ...
Bartlomiej Obrochta, Heidi Tapio, Marja Raekallio, Luis Alfonso Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Noora Jantunen, Ninja Karikoski   +7 more
wiley   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Vibegron for overactive bladder in men with benign prostatic hyperplasia/obstruction: insights from the COURAGE trial. [PDF]

Transl Androl Urol
Saadat H, Bhojani N, Elterman D, Chughtai B.   +3 more
europepmc   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Alpha-2 agonists for refractory neurological symptoms in pediatric palliative care: a scoping review. [PDF]

Front Pediatr
Salerno A, Baratiri F, La Piana C, Bincoletto A, Benini F, Zanin A.   +5 more
europepmc   +1 more source

Incidence and predictors of transurethral resection of prostate in men with and without type 2 diabetes: the Fremantle Diabetes Study Phase I

Internal Medicine Journal, Volume 55, Issue 5, Page 760-766, May 2025.
Abstract Background The relationship between type 2 diabetes and the incidence of transurethral resection of the prostate (TURP) remains uncertain. Aims To utilise data from the Fremantle Diabetes Study Phase I (FDS1) to examine the association between type 2 diabetes and incident TURP and investigate risk factors in men with type 2 diabetes.
Timothy M. E. Davis, Wendy A. Davis
wiley   +1 more source

Small fiber neuropathy with dysautonomia and positive GPCR and FGFR-3 antibodies after the first BNT162b2 dose. [PDF]

Clinics (Sao Paulo)
Finsterer J, Scorza CA, Scorza FA, Fiorini AC.   +3 more
europepmc   +1 more source

Arrhythmogenic Cardiomyopathy: Towards Genotype Based Diagnoses and Management

Journal of Cardiovascular Electrophysiology, EarlyView.
To improve arrhythmogenic cardiomyopathy (ACM) patient care four pillars of ACM research are necessary. The first pillar to improve ACM is cohort studies in which the genotype‐specific natural history of disease is described, and subsequently genotype‐specific risk calculators can be developed, such as the DSP and PLN risk calculators.
Steven A. Muller, Giorgia Bertoli, Jianan Wang, Alessio Gasperetti, Moniek G. P. J. Cox, Hugh Calkins, Anneline S. J. M. te Riele, Daniel P. Judge, Mario Delmar, Richard N. W. Hauer, Gerard J. J. Boink, Marina Cerrone, J. Peter van Tintelen, Cynthia A. James   +13 more
wiley   +1 more source