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Heterogeneity of alpha-2 adrenergic receptors
Pharmacology Biochemistry and Behavior, 1985Alpha adrenergic receptors are subdivided into alpha-1 and alpha-2 subtypes on the basis of their pharmacologic properties. An evaluation of data from radioligand binding and functional experiments indicates that the receptors classified as alpha-2 are not a homogeneous group.
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Alpha 2A adrenergic receptor gene and suicide
Psychiatry Research, 2004Suicide is a complex trait resulting from the interaction of several predisposing factors, among which genes seem to play an important role. Alterations in the noradrenergic system have been observed in postmortem brain studies of suicide victims when compared to controls.
Alain Lesage +8 more
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1988
The actions of epinephrine, an adrenal hormone and central neurotransmitter, and norepinephrine, a peripheral sympathetic and central neurotransmitter, are mediated through alpha-1, alpha-2, and beta-adrenergic receptors. In addition, a variety of drugs also produce their effects by interacting with these receptors. alpha-2 Adrenergic agonists, such as
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The actions of epinephrine, an adrenal hormone and central neurotransmitter, and norepinephrine, a peripheral sympathetic and central neurotransmitter, are mediated through alpha-1, alpha-2, and beta-adrenergic receptors. In addition, a variety of drugs also produce their effects by interacting with these receptors. alpha-2 Adrenergic agonists, such as
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Alpha adrenergic receptor mechanism: Biochemical events
Journal of Molecular and Cellular Cardiology, 1986Immediate post-receptor events following alpha-adrenoceptor stimulation in cardiac ventricular muscle are still largely unknown. Since membrane redox systems appear to be present in cell plasma membranes and may be involved in trans-sarcolemma electron efflux, the possibility that Ca2+ inflow was controlled by electron efflux was explored.
Michael G. Clark, Stephen Rattigan
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The alpha-1 Adrenergic Receptors
1987Section 1: Historical Perspectives.- 1 alpha-1 Adrenergic Receptors: A Historical Perspective.- 1. Introduction.- 2. Adrenotropic Receptors.- 3. Receptor Blockers.- 4. Recent Developments.- 5. Conclusion.- References.- Section 2: Characterization of the Receptor and Its Binding Site.- 2 Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor.-
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1980
The proper evaluation of adrenergic drugs is important not only in understanding the theoretical aspects of adrenoceptors, but also in the utilization of these substances in therapeutics. Currently, chemicals are being synthesized for organ receptor specificity.
P. N. Patil, R. R. RuffoloJr.
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The proper evaluation of adrenergic drugs is important not only in understanding the theoretical aspects of adrenoceptors, but also in the utilization of these substances in therapeutics. Currently, chemicals are being synthesized for organ receptor specificity.
P. N. Patil, R. R. RuffoloJr.
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Blockade of alpha-adrenergic receptors by analogues of phosphatidylcholine
Life Sciences, 1982The experimental evidence reviewed in this article suggests that the kidneys may have an additional function in regulating blood pressure besides their role in controlling both blood volume by urine formation and the relative state of vasoconstriction by the renin-angiotensin system.
Lawrence W. Byers +4 more
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Biochemistry of alpha-2 Adrenergic Receptors [PDF]
, 1988 Physiologic and pharmacologic studies provide the present basis for the classification of alpha-adrenergic receptors (Langer, 1974; Berthelsen and Pettinger, 1977; Wikberg, 1978; Starke, 1981). This classification calls for the existence of discrete alpha-1 and alpha-2 adrenergic receptors with the extant possibility of further subdivision among the ...
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Heterogeneity of alpha-1 Adrenergic Receptors
1987The alpha-1 adrenergic receptor, located postjunctionally on smooth muscle and other tissues, has been studied for decades, although not recognized as a specific subtype. Until recently, alpha-adrenergic receptors were not subdivided, and the alpha-adrenergic receptor-mediated responses commonly measured, such as contraction of smooth muscle in vitro ...
Robert M. DeMarinis +3 more
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Transcriptional regulation of alpha-1 adrenergic receptors
Frontiers in Bioscience, 1998Regulation of alpha1-adrenergic receptors (alpha1ARs) is a rapidly expanding field of study due to the involvement of these receptors in several human diseases. For example, upregulation of alpha1bAR mRNA/protein with agonist exposure has been implicated in myocardial hypertrophy.
Debra A. Schwinn, D R Scanga
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