Results 31 to 40 of about 85,891 (312)

Assessment of melatonin-alpha adrenergic receptor complexes by molecular docking analysis

Brazilian Journal of Biology, 2022
The pineal melatonin (N-acetyl-5-methoxytryptamine) is a molecule associated in a way or another with probably all physiological systems, aiming to fulfil its functional integrative roles in central nervous system activity, sleep and wakefulness cycles ...
V. G. Borges, J. E. Gabriel
doaj   +1 more source

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]

, 2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander, Arévalo-León, Cavalli, Chalothorn, Chen, Cotecchia, Daly, Deighan, Docherty, García-Cazarín, García-Sainz, García-Sainz, García-Sainz, Gisbert, Gisbert, Gisbert, Gisbert, Goldstein, Hawrylyshyn, Hein, Hosoda, Hrometz, Hussain, Keffel, Kenny, Koshimizu, Lachnit, Lyssand, Lyssand, Lyssand, Martinez-Rivelles, Martí, McCune, Methven, Methven, Michelotti, Monto, Noguera, Noguera, Philipp, Piascik, Piascik, Pérez-Aso, Rudner, Schwinn, Stassen, Taguchi, Tanaka, Tanoue, Tanoue, Theroux, Yamamoto, Zhong, Ziani   +53 more
core   +1 more source

An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

JACC: Basic to Translational Science, 2017
Summary: Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never ...
Ju Youn Beak, PhD, Wei Huang, Joel S. Parker, PhD, Sean T. Hicks, BS, Cam Patterson, MD, Paul C. Simpson, MD, Anqi Ma, PhD, Jian Jin, PhD, Brian C. Jensen, MD   +8 more
doaj   +1 more source

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

PLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney   +4 more
doaj   +1 more source

Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus [PDF]

, 2018
Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect.
Berry, Christina M., Corley, Sean W., Jonsson, Nicholas N., Klafke, Guilherme, Koh-Tan, H.H. Caline, Tidwell, Jason   +5 more
core   +1 more source

Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats [PDF]

Anesthesia and Pain Medicine, 2020
Background Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor.
Dong Joon Kim, Young Joon Ki, Bo Hyun Jang, Seongcheol Kim, Sang Hun Kim, Ki Tae Jung   +5 more
doaj   +1 more source

Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]

, 2011
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A., Bohr, Colin, Figueroa-Guzman, Yazmin, Graf, Evan N., Li, Shi-Jiang, Mantsch, John R., Mueller, Christopher R, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +9 more
core   +2 more sources

The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2015
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P., Kantak, Kathleen M., Somkuwar, Sucharita S.   +2 more
core   +4 more sources

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik, Beckmann, Christer, Füllhase, Claudius, Gratzke, Christian, Hedlund, Petter, Hennenberg, Martin, Montorsi, Francesco, Rutz, Beata, Stief, Christian Georg, Strittmatter, Frank, Waidelich, Raphaela   +10 more
core   +2 more sources