Results 31 to 40 of about 83,617 (230)

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

PLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney   +4 more
doaj   +1 more source

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity

JACC: Basic to Translational Science, 2017
Summary: Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never ...
Ju Youn Beak, PhD, Wei Huang, Joel S. Parker, PhD, Sean T. Hicks, BS, Cam Patterson, MD, Paul C. Simpson, MD, Anqi Ma, PhD, Jian Jin, PhD, Brian C. Jensen, MD   +8 more
doaj   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources

Role of alpha adrenergic receptors in erectile function [PDF]

International Journal of Impotence Research, 2000
Penile erection is a complex physiological process in which the regulation of penile hemodynamics depends on signal input from central and peripheral nervous systems, and on the balance and interplay between several local physiological mediators (neurotransmitters, vasoactive agents and endocrine factors).
Noel N. Kim, Robert B. Moreland, Abdulmaged M. Traish, Irwin Goldstein   +3 more
openaire   +3 more sources

Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats [PDF]

Anesthesia and Pain Medicine, 2020
Background Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor.
Dong Joon Kim, Young Joon Ki, Bo Hyun Jang, Seongcheol Kim, Sang Hun Kim, Ki Tae Jung   +5 more
doaj   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik, Beckmann, Christer, Füllhase, Claudius, Gratzke, Christian, Hedlund, Petter, Hennenberg, Martin, Montorsi, Francesco, Rutz, Beata, Stief, Christian Georg, Strittmatter, Frank, Waidelich, Raphaela   +10 more
core   +2 more sources

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2010
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Somkuwar, Sucharita S., Kantak, Kathleen M., Dwoskin, Linda P.   +2 more
core   +4 more sources

Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]

, 2011
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A., Bohr, Colin, Figueroa-Guzman, Yazmin, Graf, Evan N., Li, Shi-Jiang, Mantsch, John R., Mueller, Christopher R, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +9 more
core   +2 more sources

The Alpha-1A Adrenergic Receptor in the Rabbit Heart

PLOS ONE, 2016
The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart.
Bat-Erdene Myagmar, Bat-Erdene Myagmar, Anthony J. Baker, Anthony J. Baker, Philip M. Swigart, Patrick M. Cowley, Patrick M. Cowley, Abhishek Singh, Abhishek Singh, Paul C. Simpson, Paul C. Simpson, R. Croft Thomas, R. Croft Thomas   +12 more
openaire   +4 more sources