Results 61 to 70 of about 37,629 (265)
Arthritis &Rheumatology, Accepted Article.Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty +4 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014 Background and Objectives: Adrenergic and GABAergic systems of the brain play an important role in memory and learning. According to results of studies, morphine, histamine, and lithium induce state-dependent learning.
Morteza Piri +2 more
doaj
Trends in first‐line monotherapy and combination therapy for hypertension in UK primary care
British Journal of Clinical Pharmacology, EarlyView.Aims Debate remains about the optimal initial treatment strategy for hypertension. Most guidelines recommend first‐line combination therapy for most patients. However, the UK's National Institute for Health and Care Excellence recommends first‐line monotherapy for all patients.
Kyle Johnson +4 more
wiley +1 more source
Journal of Lipid Research, 1990 We have recently shown that functional alpha 2-adrenergic receptors, assessed by the alpha 2-agonist UK 14304, are present in rat white fat cells as in adipocytes of humans and other species.
C Carpéné +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
Glutamate Receptor Modulation Is Restricted to Synaptic Microdomains
Cell Reports, 2015 A diverse array of neuromodulators governs cellular function in the prefrontal cortex (PFC) via the activation of G-protein-coupled receptors (GPCRs). However, these functionally diverse signals are carried and amplified by a relatively small assortment ...
Gyorgy Lur, Michael J. Higley
doaj +1 more source
Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
Barrier Immunity, EarlyView.ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia +4 more
wiley +1 more source
Imipramine Increases Norepinephrine and Serotonin in the Salivary Glands of Rats
BiologyXerostomia induced by antidepressants such as imipramine has long been thought to be due to their anticholinergic effects. However, even antidepressants with low anticholinergic effects may have a high incidence of xerostomia.
Kosuke Shirose +9 more
doaj +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
The Role of Alpha-adrenergic Receptor Mechanism in Ejaculation
The Tohoku Journal of Experimental Medicine, 1972 The effects of autonomic drugs on seminal emission and ejaculation were investigated in mongrel dogs. Changes in the posterior urethral pressure (posterior urethrogram) and the volume of seminal emission during continuous hypogastric nerve stimulation were measured in test animals.
Y, Kimura +3 more
openaire +3 more sources