Results 121 to 130 of about 44,469 (168)
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Beta adrenergic receptors in lymphocyte subpopulations
Journal of Allergy and Clinical Immunology, 1980To further evaluate the potential utility of lymphocyte beta adrenergic receptor assays in the study of receptor alterations in human disease, we studied highly purified populations of B and T lymphocytes in peripheral blood to see if differences existed in the concentration or affinity of beta adrenergic receptors and catecholamine-responsive cAMP ...
N H, Bishopric +2 more
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Molecular structure of the .beta.-adrenergic receptor
Biochemistry, 1985The beta-adrenergic receptor from several tissues has been purified to homogeneity or photoaffinity radiolabeled and its subunit molecular weight determined by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. In this study we have examined the oligomeric structure of nondenatured beta 1- and beta 2-adrenergic receptor proteins, as ...
R G, Shorr +6 more
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The Beta-Adrenergic Receptor in Heart Failure
Hospital Practice, 1983Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have ...
J A, Heinsimer, R J, Lefkowitz
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Clinical Pharmacology and Therapeutics, 1986
Tertatolol is a potent new beta-blocker with no intrinsic sympathomimetic activity or beta 1/beta 2-receptor subtype selectivity. When given at therapeutic doses (5 mg/day) to human subjects it induced a reduction in the beta-adrenergic receptor number measured by 3H-CGP 12177 specific binding, without any change in the affinity on intact lymphocytes ...
DE BLASI, ANTONIO +5 more
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Tertatolol is a potent new beta-blocker with no intrinsic sympathomimetic activity or beta 1/beta 2-receptor subtype selectivity. When given at therapeutic doses (5 mg/day) to human subjects it induced a reduction in the beta-adrenergic receptor number measured by 3H-CGP 12177 specific binding, without any change in the affinity on intact lymphocytes ...
DE BLASI, ANTONIO +5 more
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Perspectives in adrenergic beta‐receptor blockade
Clinical Pharmacology & Therapeutics, 1969The adrenergic ß‐receptor blocking drugs currently undergoing clinical evaluation are classified in relation to their pharmacological properties. Particular consideration is given to those pharmacological properties that may be of importance in the clinical application of these drugs.
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The beta-adrenergic receptors.
Herz, 2003The beta-adrenergic receptors of the myocardium play an important role in the regulation of heart function. The beta-adrenergic receptors belong to the family of G-protein coupled receptors. Three subtypes have been distinguished (beta1-, beta2-, and beta3-adrenoceptors).
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Antibodies to Beta-Adrenergic Receptors
1991Contemporary biochemists and molecular biologists strive to understand the relationship between the function and the detailed chemical structure of macromolecules. Whereas chemical and direct physical analyses are employed to probe molecular structure, specific antibodies to proteins have been invaluable reagents in the determination of the fine ...
Craig C. Malbon +2 more
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BLOCKADE OF THE BETA ADRENERGIC RECEPTORS
The Journal of Pharmacology and Experimental Therapeutics, 1960B, LEVY, R P, AHLQUIST
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Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors
Pharmacology, 2000β<sub>1</sub>- and β<sub>2</sub>-adrenergic receptors are G protein-coupled receptors expressed throughout the body and serve as receptors for the catecholamines epinephrine and norepinephrine. They are targets for therapeutive agonists and/or antagonists in treatment of heart failure and asthma.
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