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Autoantibodies and Beta-Adrenergic Receptors

New England Journal of Medicine, 1981
IN recent years it has been recognized that autoantibodies to cell-surface receptors for hormones or neurohumoral agents can develop spontaneously and give rise to clinical states of altered endocrine or neuromuscular function. For example, autoantibodies to receptors for acetylcholine in skeletal muscle are associated with myasthenia gravis, those to ...
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Beta Adrenergic Receptors

2014
β-Adrenergic receptors (β-ARs) have a key position not in to the overall regulation of cardiac function and have been shown to play an important role in various cardiac diseases and heart failure in particular. Beta adrenergic receptors (β-ARs) belong to the G protein-coupled receptor (GPCR) superfamily with widespread expression and cardiovascular ...
Konstantinos Makaritsis   +1 more
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Biotechnology of β-adrenergic receptors

Molecular Neurobiology, 1990
This article discusses the structural and functional features of a new family of membrane receptors including alpha-adrenergic and beta-adrenergic receptors for catecholamines, muscarinic receptors for acetylcholine, and receptors for histamine, dopamine, serotonin, and neuropeptides such as angiotensin.
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Beta adrenergic receptors in the parathyroid glands

Naunyn-Schmiedeberg's Archives of Pharmacology, 1980
The location of beta-adrenoceptors in human parathyroid gland was studied using an immunohistochemical method. Frozen sections of human parathyroid glands, taken from surgical samples, were treated with (-)-alprenolol, washed and exposed to (-)-alprenolol antibodies conjugated with fluorescent dyes.
Francesco Amenta   +3 more
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Tocolysis with beta-adrenergic receptor agonists

Seminars in Perinatology, 2001
Beta-adrenergic receptor agonists have been used for tocolysis in the setting of preterm labor for more than three decades. One of these agents, ritodrine hydrochloride, is the only Federal Drug Administration (FDA) approved drug for the treatment of preterm labor.
A B, Caughey, J T, Parer
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Beta-Adrenergic Receptors

1991
The catecholamines epinephrine and norepinephrine evoke specific beta-adrenergic responses in a variety of tissues.Examples of processes modulated by these agonists are chronotropic and inotropic cardiac responses, relaxation of smooth muscle, and lipolysis in adipose tissue.The facts that beta-adrenergic responses are limited to specific tissues and ...
Jeffrey M. Stadel, Robert J. Lefkowitz
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Molecular structure of the .beta.-adrenergic receptor

Biochemistry, 1985
The beta-adrenergic receptor from several tissues has been purified to homogeneity or photoaffinity radiolabeled and its subunit molecular weight determined by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. In this study we have examined the oligomeric structure of nondenatured beta 1- and beta 2-adrenergic receptor proteins, as ...
R G, Shorr   +6 more
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The Beta-Adrenergic Receptor in Heart Failure

Hospital Practice, 1983
Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have ...
J A, Heinsimer, R J, Lefkowitz
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Perspectives in adrenergic beta‐receptor blockade

Clinical Pharmacology & Therapeutics, 1969
The adrenergic ß‐receptor blocking drugs currently undergoing clinical evaluation are classified in relation to their pharmacological properties. Particular consideration is given to those pharmacological properties that may be of importance in the clinical application of these drugs.
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The beta-adrenergic receptors.

Herz, 2003
The beta-adrenergic receptors of the myocardium play an important role in the regulation of heart function. The beta-adrenergic receptors belong to the family of G-protein coupled receptors. Three subtypes have been distinguished (beta1-, beta2-, and beta3-adrenoceptors).
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