Results 41 to 50 of about 94,483 (313)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Beta-adrenergic blocking agents in cutaneous and oral melanoma

Oral Oncology Reports
Beta-adrenergic blocking agents, or beta-blockers, are primarily used to manage cardiovascular conditions such as hypertension, heart failure, and arrhythmias by blocking the effects of stress hormones on beta-adrenergic receptors, reducing heart rate ...
Sivakamavalli Jeyachandran
doaj   +1 more source

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. [PDF]

, 1986
Prolonged exposure of cells or tissues to drugs or hormones such as catecholamines leads to a state of refractoriness to further stimulation by that agent, known as homologous desensitization.
Benovic, JL, Daniel, K, Lefkowitz, RJ, Sibley, DR, Strasser, RH   +4 more
core  

Adverse Effects on beta-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function [PDF]

, 2017
BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury.
Abdallah Y, Bencsik, Péter, Csonka, Csaba, Ferdinandy, Péter, Gömöri, Kamilla, Kiss, Krisztina, Pipis J, Pálóczi, János, Schluter KD, Schreckenberg R, Schulz R, Sárközy, Márta, Weber M   +12 more
core   +3 more sources

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue–Related Raynaud Phenomenon in the United States

Arthritis Care &Research, EarlyView.
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech, Charles G. Frech, W. David Merryman, Andrew Sternlicht, Justin Baba   +4 more
wiley   +1 more source

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Journal of Neuroinflammation
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in ...
Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo   +12 more
doaj   +1 more source

A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.

Journal of Lipid Research, 1988
The beta-adrenergic receptors of isolated human fat cells were identified using a new hydrophilic beta-adrenergic radioligand (+/-)[3H]CGP-12177. The results were compared with those from [3H]dihydroalprenolol binding to fat cells and membranes.
D Lacasa, P Mauriège, M Lafontan, M Berlan, Y Giudicelli   +4 more
doaj   +1 more source

Beta-Blockers and Cancer: Where Are We?

Pharmaceuticals, 2020
Cancer is one of the leading causes of death worldwide. After diagnosis, cancer treatment may involve radiotherapy, chemotherapy, and surgery. Several of the approaches used to treat cancer also attack normal cells and, thus, there is the need for more ...
Rita Peixoto, Maria de Lourdes Pereira, Miguel Oliveira   +2 more
doaj   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core   +1 more source

Pharmacogenetics of the human beta-adrenergic receptors [PDF]

The Pharmacogenomics Journal, 2006
The beta-adrenergic receptors (ADRBs) are cell surface receptors that play central roles in the sympathetic nervous system. Pharmacological targeting of two of these receptors, ADRB1 and ADRB2, represents a widely used therapeutic approach for common and important diseases including asthma, hypertension and heart failure.
openaire   +2 more sources