Results 101 to 110 of about 86,830 (247)

Cell swelling enhances ligand-driven β-adrenergic signaling

Nature Communications
G protein-coupled receptors’ conformational landscape can be affected by their local, microscopic interactions within the cell plasma membrane. We employ here a pleiotropic stimulus, namely osmotic swelling, to alter the cortical environment within ...
Alexei Sirbu, Marc Bathe-Peters, Jothi L. M. Kumar, Asuka Inoue, Martin J. Lohse, Paolo Annibale   +5 more
doaj   +1 more source

Lower Urinary Tract Symptoms in Male Patients With Multiple Sclerosis: Prevalence and Associations With Quality of Life, Depression, and Anxiety

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose Lower urinary tract symptoms (LUTS) are frequent in male patients with multiple sclerosis (MS). This study was planned to investigate the frequency and distress of LUTS in men with MS and their association with quality of life (QoL), depression, and anxiety. Methods One hundred male patients with MS were included in the study.
Yesim Akkoc, Bedriye Karaman, Asli Koskderelioglu, Ozgul Ekmekci, Neslihan Eskut, Nur Yuceyar   +5 more
wiley   +1 more source

Association of obesity and body mass index classification with glycemic control in adults who are critically ill receiving parenteral nutrition: A retrospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Hyperglycemia is a complication of parenteral nutrition (PN), which can be exacerbated in patients with obesity. Limited data exist on glycemic control in this population. This study aims to evaluate the association of obesity and body mass index (BMI) classification with glycemic control in patients who are critically ill initiated
Erika L. Mackie, Melissa Dang, Kimberly Sharpe, Justin Delic, James M. Hollands, Song Oh, Stacy Pasciolla, Laura Pontiggia, Diana Solomon, Angela Bingham   +9 more
wiley   +1 more source

Antiobesity Medications for Older Adults—the New, the Good, the Bad, and the Unknown

Obesity, EarlyView.
ABSTRACT Objective Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non‐modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be
Anna Pendrey, Javier Sevilla‐Martir
wiley   +1 more source

Nectar concentrations of biogenic amines affect bumble bee behavior in a dose‐dependent manner

Oikos, EarlyView.
While foraging, pollinators encounter a wide array of molecules, some of which may influence their internal states and behaviors. Among these, biogenic amines – nitrogenous compounds that serve as essential neuromodulators in animals – have only recently been detected in floral nectar.
Marta Barberis, Daniele Calabrese, David Baracchi, Laura Bortolotti, Flavia Di Cesare, Rosa Ranalli, Laura Zavatta, Massimo Nepi, Marta Galloni, Gherardo Bogo   +9 more
wiley   +1 more source

Expanding the Reach of Membrane Protein–Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

PROTEOMICS, EarlyView.
ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos, Ashim Bhattacharya, Mohammed Al‐Seragi, Franck Duong van Hoa   +3 more
wiley   +1 more source

Lung‐Derived Small Extracellular Vesicles Containing miR‐15a‐5p/miR‐96‐5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7

Small, EarlyView.
Small extracellular vesicles (sEVs) are critical regulators of inter‐tissue communication in cardiovascular diseases. In this study, it is found that lung‐derived sEVs enhance cardiac fibroblasts activation and aggravates myocardial fibrosis progression in hypertrophic cardiomyopathy (HCM). sEVmiR‐15a‐5p and sEVmiR‐96‐5p exert this effect via targeting
Minwen Long, Jinpeng Sun, Dongli Zhou, Can Chen, Jiangcheng Shu, Xiaobo Mao, Kunwu Yu, Minglu Liang, Long Chen, Yumei Wang, Min Cheng   +10 more
wiley   +1 more source

Dual‐Targeted Glucose‐Dependent Insulinotropic Polypeptide‐Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue

Small Science, EarlyView.
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie, Lutang Zhao, Shurui Pei, Kaikai Wen, Sijia Fei, Wan Chen, Zhengyang Li, Long Zhang, Linlin Li, Lixin Guo, Hui Huang, Qi Pan   +11 more
wiley   +1 more source

Atypical presentation of pheochromocytoma as acute ischemic stroke and pulmonary embolism, a case report

UroPrecision, EarlyView.
Abstract Background Pheochromocytoma is a rare catecholamine‐secreting tumor that often presents with symptoms such as hypertension, palpitations, and sweating due to excessive hormone production. In some cases, the catecholamine‐induced vasoconstriction and hypercoagulability associated with pheochromocytomas can lead to cerebrovascular accidents and ...
Mohannad N. AbuHaweeleh, Ahmad Yousef Al‐maslamani, Majd A. AbuAlrob, Abdelrahman Elsayed, Mahmoud Altayyan, Osama Khalil, Ahmad Abdulhadi   +6 more
wiley   +1 more source

Glucose sensing and homeostasis by adipocyte GPCR. [PDF]

Front Endocrinol (Lausanne)
Hasan N, Chhabra KH.
europepmc   +1 more source