Results 231 to 240 of about 164,312 (330)

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The Use of Neurons Derived from Pluripotent Stem Cells to Study Nerve-Cancer Cell Interactions. [PDF]

Int J Mol Sci
Jiménez A, López-Ornelas A, Gutiérrez-de la Cruz N, Puente-Rivera J, Mayen-Quinto RD, Sánchez-Monciváis A, Ignacio-Mejía I, Albores-Méndez EM, Vargas-Hernández MA, Estudillo E.   +9 more
europepmc   +1 more source

Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, EarlyView.
The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley   +1 more source

Single-cell RNA sequencing reveals adrb1 as a sympathetic nerve-regulated immune checkpoint driving T cell exhaustion and impacting immunotherapy in esophageal squamous cell carcinoma. [PDF]

Front Immunol
Li Q, Xu S, Ren Y, Zhang C, Li K, Liu Y.
europepmc   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells. [PDF]

J Physiol Sci
Asaka Y, Masumoto T, Uneda A, Chin VD, Otani Y, Peña T, Katayama H, Itano T, Ando T, Huang R, Fujimura A.   +10 more
europepmc   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source

Metabolic control of ovarian function through the sympathetic nervous system: role of leptin. [PDF]

Front Endocrinol (Lausanne)
Astudillo-Guerrero C, Paredes AH, Escobar J, Fernandois D, Barra R, Cruz G.   +5 more
europepmc   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source