Results 151 to 160 of about 106,627 (314)

Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin

IJU Case Reports, Volume 6, Issue 1, Page 37-40, January 2023., 2023
Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose) polymerase inhibitors such as olaparib.
Yoshiyuki Miyazawa, Takanori Shimizu, Yoshitaka Sekine, Seiji Arai, Akira Ohtsu, Yuji Fujizuka, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +9 more
wiley   +1 more source

N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats: Focus on oxidative and sex hormone receptors mechanisms

Asian Pacific Journal of Reproduction
Objective: To investigate the potential of N-acetylcysteine (NAC) and zinc sulphate (ZnSO4) in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate (DEHP) in rats and to understand the underlying mechanisms, specifically oxidative ...
Victor Oghenekparobo Emojevwe, Mega Obukohwo Oyovwi, Kayode Ezekiel Adewole, Peggy Ejiro Ohwin, Adeniran Oluwadamilare Akinola, Alexander Obidike Naiho, Eze Kingsley Nwangwa, Victor Omo-Idonije, Motunrayo Lade-Ige, Benneth Ben-Azu   +9 more
doaj   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

A CRH Theory of Autism Spectrum Disorder [PDF]

arXiv
This paper presents a complete theory of autism spectrum disorder (ASD), explaining its etiology, symptoms, and pathology. The core cause of ASD is excessive stress-induced postnatal release of corticotropin-releasing hormone (CRH). CRH competes with urocortins for binding to the CRH2 receptor, impairing their essential function in the utilization of ...
arxiv  

Molecular Defects of the Androgen Receptor

Recent Progress in Hormone Research, 1999
Defects of the androgen receptor cause a wide spectrum of abnormalities of phenotypic male development, ranging from individuals with mild defects of virilization to those with complete female phenotypes. In parallel with this phenotypic spectrum, a large number of different mutations have been identified that alter the synthesis or functional activity
openaire   +4 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Sexing Bones: Improving Transparency of Sex Reporting to Address Bias Within Preclinical Studies

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 5-13, January 2023., 2023
ABSTRACT Despite knowledge that sexually dimorphic mechanisms regulate bone homeostasis, sex often remains unreported and unconsidered in preclinical experimental design. Failure to report sex could lead to inappropriate generalizations of research findings and less effective translation into clinical practice.
Aikta Sharma, Lysanne V Michels, Andrew A Pitsillides, Julie Greeves, Lillian I Plotkin, Valentina Cardo, Natalie A Sims, Claire E Clarkin   +7 more
wiley   +1 more source

Hormone Receptors in Cervicovaginal Cells

Gynecology Obstetrics & Reproductive Medicine, 2013
Some parts of the female reproductive system such as vagina and ectocervix is covered with stratified squamous epithelium (SSE). SSE consists of many layers and steroid hormones are essential for its normal growth and development.
Şayeste Demirezen, Funda Gerçeker, Sinan Beksaç   +2 more
doaj  

Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer

Analytical Cellular Pathology, 2019
Kaempferol is a well-known natural flavonol reported to be a potential treatment for multiple cancers. In this study, we demonstrated that cell growth of androgen-sensitive LNCaP cells could be inhibited 33% by 5 μM kaempferol, around 60% by 10 μM ...
Jun Da, Mingxi Xu, Yiwei Wang, Wenfeng Li, Mujun Lu, Zhong Wang   +5 more
doaj   +1 more source

The challenge hypothesis revisited: Focus on reproductive experience and neural mechanisms. [PDF]

, 2020
Our review focuses on findings from mammals as part of a Special Issue "30th Anniversary of the Challenge Hypothesis". Here we put forth an integration of the mechanisms through which testosterone controls territorial behavior and consider how ...
Marler, Catherine A, Trainor, Brian C
core   +1 more source