Results 191 to 200 of about 106,627 (314)

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

arXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

A Candidate Subspecies Discrimination System Involving a Vomeronasal Receptor Gene with Different Alleles Fixed in \u3ci\u3eM. m. domesticus\u3c/i\u3e and \u3ci\u3eM. m. musculus\u3c/i\u3e [PDF]

, 2010
Assortative mating, a potentially efficient prezygotic reproductive barrier, may prevent loss of genetic potential by avoiding the production of unfit hybrids (i.e., because of hybrid infertility or hybrid breakdown) that occur at regions of secondary ...
Karn, Robert C., Laukaitis, Christina M., Young, Janet M.   +2 more
core   +1 more source

A correlative biomarker study and integrative prognostic model in chemotherapy‐naïve metastatic castration‐resistant prostate cancer treated with enzalutamide

The Prostate, Volume 83, Issue 4, Page 376-384, March 2023., 2023
Abstract Background There is a considerable need to incorporate biomarkers of resistance to new antiandrogen agents in the management of castration‐resistant prostate cancer (CRPC). Methods We conducted a phase II trial of enzalutamide in first‐line chemo‐naïve asymptomatic or minimally symptomatic mCRPC and analyzed the prognostic value of TMPRSS2‐ERG
María P. Fernandez‐Perez, Enrique Perez‐Navarro, Teresa Alonso‐Gordoa, Vicenza Conteduca, Albert Font, Sergio Vázquez‐Estévez, Aránzazu González‐del‐Alba, Daniel Wetterskog, Emmanuel S. Antonarakis, Begona Mellado, Ovidio Fernandez‐Calvo, María J. Méndez‐Vidal, Miguel A. Climent, Ignacio Duran, Enrique Gallardo, Angel Rodriguez Sanchez, Carmen Santander, Maria I. Sáez, Javier Puente, Julian Tudela, Alberto Martínez, Maria J. López‐Andreo, José Padilla, Rebeca Lozano, David Hervas, Jun Luo, Ugo de Giorgi, Daniel Castellano, Gerhardt Attard, Enrique Grande, Enrique Gonzalez‐Billalabeitia   +30 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment

Food Frontiers, EarlyView.
Natural small molecules through nanocarriers for cancer treatment ABSTRACT Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude of studies have indicated that naturally sourced small‐molecule compounds, owing to their low toxicity and multi‐target capabilities, significantly aid in the fight ...
Fangting Ye, Shaojie Zheng, Shuo Shan, Jiaer Cai, Yufan Liu, Weichao Chen, Xinxin He, Chao Zhao   +7 more
wiley   +1 more source

Hovenia dulcis Honey Suppresses Androgen‐Induced Epithelial–Mesenchymal Transition in Benign Prostatic Hyperplasia

Food Frontiers, EarlyView.
HH inhibits the androgen/AR and TGF‐β1/Smad signaling pathways, and may offer a novel therapeutic approach for BPH treatment. ABSTRACT Benign prostate hyperplasia (BPH) is characterized by abnormal prostate epithelial and stromal cell growth, which leads to bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS).
Buyun Kim, Young‐Eun Kim, Eun‐Bin Kwon, Wei Li, Hye Jin Yang, Sung‐Joon Na, Sang Mi Han, Soon Ok Woo, Hong Min Choi, Siwon Moon, Young Soo Kim, Jang‐Gi Choi   +11 more
wiley   +1 more source

Behavioral Responses to Healthcare Funding Decisions and Their Impact on Value for Money: Evidence From Australia

Health Economics, EarlyView.
ABSTRACT Value for money is fundamental to health insurance schemes given insurers must choose which treatments to fund. Assessing value for money ex ante is challenging, however, because costs and outcomes depend on how treatments are used. Estimates often rely on evidence from early randomized controlled trials conducted prior to regulatory approval,
Peter Ghijben, Dennis Petrie, Silva Zavarsek, Gang Chen, Emily Lancsar   +4 more
wiley   +1 more source

Functional, pathogenic, and pharmacological roles of protein folding intermediates

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley   +1 more source

Clinical Outcomes of Intensity Modulated Proton Therapy for Salivary Gland Carcinoma: High Local Control and Quality of Life Preservation

Head &Neck, EarlyView.
ABSTRACT Background In recent years, particle therapy has shown promise as a local treatment for salivary gland carcinoma (SGC); however, its efficacy and safety remain unclear. This study aimed to evaluate the clinical outcomes of intensity‐modulated proton therapy (IMPT) for SGC.
Gaku Takano, Daisuke Kawakita, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Yusuke Tsuzuki, Shuou Sudo, Toshiyuki Toshito, Kensuke Hayashi, Takuma Matoba, Michi Sawabe, Kiyoshi Minohara, Sho Iwaki, Kazuyuki Nakai, Yu Iwase, Shinichi Iwasaki, Hiroyuki Ogino   +16 more
wiley   +1 more source