Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Oestrogenic and androgenic activity of oxybenzone and methylparaben <i>in vitro</i>. [PDF]
Arh Hig Rada ToksikolPeranić N, Božičević L, Vrček IV.
europepmc +1 more source
The transcription factor RIP140 regulates interferon γ signaling in breast cancer
International Journal of Cancer, EarlyView.What's New? Interferon γ (IFNγ) is a key player in breast cancer, with the potential to induce apoptosis and to shift tumors into a dormant state. However, it also may promote carcinogenesis and angiogenesis. In this study, transcriptomic analysis identified the transcription factor RIP140 as a key regulator of IFNγ signaling in breast cancer.
Stéphan Jalaguier +9 more
wiley +1 more source
Androgen and Androgen Receptor in Kidney Cancer [PDF]
Nephrology - Open Journal, 2015 Joshua Cho +2 more
openaire +1 more source
Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, EarlyView.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
In Response to "Photosensitizing Drugs and Risk of Skin Cancer in Women-A Prospective Population-Based Study". [PDF]
Photodermatol Photoimmunol PhotomedBirrell SN.
europepmc +1 more source
International Journal of Cancer, EarlyView.Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder +2 more
wiley +1 more source
Emerging roles of BET proteins in transcription and co‐transcriptional RNA processing
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Roles of BET proteins in RNA polymerase II transcription and co‐transcriptional RNA processing. Abstract Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein‐coding and a large set of non‐coding RNAs, and is strictly regulated and coordinated with RNA processing.
Nicole Eischer +2 more
wiley +1 more source
Sexual Size Dimorphism Correlates With the Number of Androgen Response Elements in Mammals, But Only in Small-Bodied Species. [PDF]
Genome Biol EvolGhione CR, Dean MD.
europepmc +1 more source